PSMD14

Gene Symbol	PSMD14
Entrez Gene	10213
Alt Symbol	PAD1, POH1, RPN11
Species	Human
Gene Type	protein-coding
Description	proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
Other Description	26S proteasome non-ATPase regulatory subunit 14\|26S proteasome regulatory subunit rpn11\|26S proteasome-associated PAD1 homolog 1
Swissprots	O00176 O00487 B3KNW2
Accessions	AAX88940 AAY15016 EAX11370 O00487 AB209220 BAD92457 AK055128 BAG51474 AK091095 BC009524 AAH09524 BC066336 AAH66336 BM978668 DA133201 U86782 AAC51866 NM_005805 NP_005796
Function	Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading. {ECO:0000269\|PubMed:22909820, ECO:0000269\|PubMed:9374539}.
Tissue Specificity	Widely expressed. Highest levels in heart and skeletal muscle. {ECO:0000269\|PubMed:9374539}.
Top Pathways	Proteasome, Epstein-Barr virus infection

PSMD14 Antibody - 7662 from Cell Signaling Technology

Prices	$239.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts from various cell lines using PSMD14 Antibody.

PSMD14 (D18C7) Rabbit mAb - 4197 from Cell Signaling Technology

Prices	$246.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Monoclonal
Clone	D18C7

Western blot analysis of extracts from various cell lines using PSMD14 (D18C7) Rabbit mAb.

POH1 (SQ-17) - sc-100464 from Santa Cruz Biotechnology

Prices	$295.00
Sizes	100 µg/ml
Host	Mouse
Clonality	Monoclonal

POH1 (SQ-17): sc-100464. Western blot analysis of POH1 expression in A-431 whole cell lysate.

Anti-PSMD14 antibody - ab140496 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-PSMD14 antibody (ab140496) at 0.4 µg/mlLane 1 : 293T whole cell lysate at 50 µgLane 2 : 293T whole cell lysate at 15 µgLane 3 : HeLa whole cell lysate at 50 µgLane 4 : Jurkat whole cell lysate at 50 µgLane 5 : NIH3T3 whole cell lysate at 50 µgdeveloped using the ECL technique

Anti-PSMD14 antibody - ab182762 from Abcam

Prices	$376.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue labeling PSMD14 with ab182762 at 1/20 dilution (left panel). Right panel is treated with the immunogen.

Anti-PSMD14 antibody - ab168779 from Abcam

Prices	$376.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

All lanes : Anti-PSMD14 antibody (ab168779) at 1 µg/mlLane 1 : PSMD14 transfected 293T cell lysateLane 2 : Non transfected 293T cell lysateLysates/proteins at 15 µl per lane.

Anti-PSMD14 antibody - ab56642 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Anti-PSMD14 antibody [EPR4257] - ab109123 from Abcam

Prices	$385.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR4257

All lanes : Anti-PSMD14 antibody [EPR4257] (ab109123) at 1/1000 dilutionLane 1 : HepG2 cell lysatesLane 2 : A431 cell lysatesLane 3 : HeLa cell lysatesLane 4 : Namalwa cell lysatesLane 5 : K562 cell lysatesLane 6 : MCF7 cell lysatesLysates/proteins at 10 µg per lane.SecondaryHRP labelled Goat anti-Rabbit at 1/2000 dilution

Anti-PSMD14 antibody [EPR4258] - ab109130 from Abcam

Prices	$379.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR4258

All lanes : Anti-PSMD14 antibody [EPR4258] (ab109130) at 1/1000 dilutionLane 1 : HepG2 cell lysateLane 2 : A431 cell lysateLane 3 : K562 cell lysateLane 4 : Namalwa cell lysateLane 5 : HeLa cell lysateLane 6 : MCF7 cell lysateLysates/proteins at 10 µg per lane.

Anti-PSMD14 antibody - C-terminal - ab139089 from Abcam

Prices	$376.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Anti-PSMD14 antibody - C-terminal (ab139089) at 1/100 dilution + HepG2 cell line lysates at 35 µgdeveloped using the ECL technique

Anti-PSMD14 Antibody (aa257-287) - LS-C158750 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

PSMD14 Antibody western blot of HepG2 cell line lysates (35 ug/lane). The PSMD14 antibody detected the PSMD14 protein (arrow).

Anti-PSMD14 Antibody (Internal, clone EPR4257) - LS-C137883 from LifeSpan Bioscience

Prices	$485.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR4257

IHC of paraffin-embedded human colon tissue using anti-POH1 antibody.

Anti-PSMD14 Antibody (aa260-310) - LS-C290506 from LifeSpan Bioscience

Prices	$375.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Detection of Human PSMD14 by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP; 20% of IP loaded) from 293T cells. Antibodies: Affinity purified rabbit anti-PSMD14 antibody used for IP at 6 ug/mg lysate. PSMD14 was also immunoprecipitated by rabbit anti-PSMD14 antibody BL13929. For blotting immunoprecipitated PSMD14, was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.

Anti-PSMD14 Antibody (C-Terminus) - LS-C17326 from LifeSpan Bioscience

Prices	$495.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-PSMD14 Antibody (aa257-287, AP) - LS-C217002 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-PSMD14 Antibody (C-Terminus) - LS-C30069 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-PSMD14 Antibody (N-Terminus) - LS-C30747 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-PSMD14 Antibody (aa257-287, APC) - LS-C217003 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-PSMD14 Antibody (aa257-287, Biotin) - LS-C217004 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-PSMD14 Antibody (aa257-287, FITC) - LS-C217005 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-PSMD14 Antibody (Internal, clone EPR4258) - LS-C137821 from LifeSpan Bioscience

Prices	$475.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR4258

Western blot analysis on (A) HepG2, (B) A431, (C) K562, (D) Namalwa, (E) HeLa, and (F) MCF-7 cell lysates using anti-POH1 antibody.

Anti-PSMD14 Antibody (aa257-287, Azide-free, HRP) - LS-C217006 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-PSMD14 Antibody (aa257-287, PE) - LS-C217008 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-PSMD14 Antibody (aa1-96, Azide-free, HRP) - LS-C220461 from LifeSpan Bioscience

Prices	$620.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal

Anti-PSMD14 Antibody (aa1-96, Azide-free) - LS-C328342 from LifeSpan Bioscience

Prices	$485.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

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