| Gene Symbol |
PSMD14
|
| Entrez Gene |
10213
|
| Alt Symbol |
PAD1, POH1, RPN11
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
|
| Other Description |
26S proteasome non-ATPase regulatory subunit 14|26S proteasome regulatory subunit rpn11|26S proteasome-associated PAD1 homolog 1
|
| Swissprots |
O00176 O00487 B3KNW2
|
| Accessions |
AAX88940 AAY15016 EAX11370 O00487 AB209220 BAD92457 AK055128 BAG51474 AK091095 BC009524 AAH09524 BC066336 AAH66336 BM978668 DA133201 U86782 AAC51866 NM_005805 NP_005796
|
| Function |
Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading. {ECO:0000269|PubMed:22909820, ECO:0000269|PubMed:9374539}.
|
| Tissue Specificity |
Widely expressed. Highest levels in heart and skeletal muscle. {ECO:0000269|PubMed:9374539}.
|
| Top Pathways |
Proteasome, Epstein-Barr virus infection
|