TXNIP

Gene Symbol	TXNIP
Entrez Gene	10628
Alt Symbol	EST01027, HHCPA78, THIF, VDUP1
Species	Human
Gene Type	protein-coding
Description	thioredoxin interacting protein
Other Description	thioredoxin binding protein 2|thioredoxin-binding protein 2|thioredoxin-interacting protein|upregulated by 1,25-dihydroxyvitamin D-3|vitamin D3 up-regulated protein 1
Swissprots	Q6PML0 Q16226 B4E3D3 Q9BXG9 Q9H3M7
Accessions	AAK37514 BAB18859 CAI22351 CAI22352 CCA65310 CCD57098 CCQ43360 EAW71410 EAW71411 Q9H3M7 AA805348 AK226090 AK301148 BAG62739 AK301203 BAG62780 AK304670 BAG65445 AY594328 AAT01927 BC024305 BC093702 AAH93702 BC093704 AAH93704 BF446648 BX404012 BX537824 DB058019 HY177853 S73591 AAB31977 NM_006472 NP_006463
Function	May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over- expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1). {ECO:0000269|PubMed:12821938, ECO:0000269|PubMed:17603038, ECO:0000269|PubMed:18541147, ECO:0000269|PubMed:21460850}.
Subcellular Location	Cytoplasm {ECO:0000250}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TXNIP Gene ORF cDNA clone in cloning vector - HG16553-G from Sino Biological Species Human

Human TXNIP Gene ORF cDNA clone expression plasmid, N-Myc tag - HG16553-NM from Sino Biological Species Human

Human TXNIP Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG16553-ACG from Sino Biological Species Human

Human TXNIP Gene ORF cDNA clone expression plasmid, N-HA tag - HG16553-NY from Sino Biological Species Human

Human TXNIP Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG16553-ANG from Sino Biological Species Human

Human TXNIP Gene ORF cDNA clone expression plasmid, N-His tag - HG16553-NH from Sino Biological Species Human

Human TXNIP Gene ORF cDNA clone expression plasmid, C-Flag tag - HG16553-CF from Sino Biological Species Human

Human TXNIP Gene ORF cDNA clone expression plasmid, C-His tag - HG16553-CH from Sino Biological Species Human

Human TXNIP Gene ORF cDNA clone expression plasmid, N-Flag tag - HG16553-NF from Sino Biological Species Human

Human TXNIP Gene ORF cDNA clone expression plasmid - HG16553-UT from Sino Biological Species Human

Human TXNIP Gene ORF cDNA clone expression plasmid, C-Myc tag - HG16553-CM from Sino Biological Species Human

Human TXNIP Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG16553-ACR from Sino Biological Species Human

Human TXNIP Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG16553-ANR from Sino Biological Species Human

Human TXNIP Gene ORF cDNA clone expression plasmid, C-HA tag - HG16553-CY from Sino Biological Species Human

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