TXNIP

Gene Symbol TXNIP
Entrez Gene 10628
Alt Symbol EST01027, HHCPA78, THIF, VDUP1
Species Human
Gene Type protein-coding
Description thioredoxin interacting protein
Other Description thioredoxin binding protein 2|thioredoxin-binding protein 2|thioredoxin-interacting protein|upregulated by 1,25-dihydroxyvitamin D-3|vitamin D3 up-regulated protein 1
Swissprots Q6PML0 Q16226 B4E3D3 Q9BXG9 Q9H3M7
Accessions AAK37514 BAB18859 CAI22351 CAI22352 CCA65310 CCD57098 CCQ43360 EAW71410 EAW71411 Q9H3M7 AA805348 AK226090 AK301148 BAG62739 AK301203 BAG62780 AK304670 BAG65445 AY594328 AAT01927 BC024305 BC093702 AAH93702 BC093704 AAH93704 BF446648 BX404012 BX537824 DB058019 HY177853 S73591 AAB31977 NM_006472 NP_006463
Function May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over- expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1). {ECO:0000269|PubMed:12821938, ECO:0000269|PubMed:17603038, ECO:0000269|PubMed:18541147, ECO:0000269|PubMed:21460850}.
Subcellular Location Cytoplasm {ECO:0000250}.

VDUP1 CRISPR/Cas9 KO Plasmid (h) - sc-400664 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

VDUP1 HDR Plasmid (h) - sc-400664-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

VDUP1 Double Nickase Plasmid (h) - sc-400664-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

VDUP1 Double Nickase Plasmid (h2) - sc-400664-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

VDUP1 CRISPR Activation Plasmid (h) - sc-400664-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

VDUP1 CRISPR Activation Plasmid (h2) - sc-400664-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

VDUP1 Lentiviral Activation Particles (h) - sc-400664-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

VDUP1 Lentiviral Activation Particles (h2) - sc-400664-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

VDUP1 siRNA (h) - sc-44943 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

VDUP1 shRNA Plasmid (h) - sc-44943-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

VDUP1 shRNA (h) Lentiviral Particles - sc-44943-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU016631 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22313 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22313 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

TXNIP siRNA (Human) - CRH7239 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TXNIP - MBS829624 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human TXNIP (NM_006472.3) - SHH438328 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human TXNIP(NM_006472.3) - SHL108360 from Creative biogene

Category siRNA
Species Reactivities Human

TXNIP shRNA Plasmid (Human) - CHH7239 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

TXNIP miRNA 3'UTR clone - MiUTR1H-10902 from Creative biogene

Species Reactivities Human
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