TXNIP

Gene Symbol TXNIP
Entrez Gene 10628
Alt Symbol EST01027, HHCPA78, THIF, VDUP1
Species Human
Gene Type protein-coding
Description thioredoxin interacting protein
Other Description thioredoxin binding protein 2|thioredoxin-binding protein 2|thioredoxin-interacting protein|upregulated by 1,25-dihydroxyvitamin D-3|vitamin D3 up-regulated protein 1
Swissprots Q6PML0 Q16226 B4E3D3 Q9BXG9 Q9H3M7
Accessions AAK37514 BAB18859 CAI22351 CAI22352 CCA65310 CCD57098 CCQ43360 EAW71410 EAW71411 Q9H3M7 AA805348 AK226090 AK301148 BAG62739 AK301203 BAG62780 AK304670 BAG65445 AY594328 AAT01927 BC024305 BC093702 AAH93702 BC093704 AAH93704 BF446648 BX404012 BX537824 DB058019 HY177853 S73591 AAB31977 NM_006472 NP_006463
Function May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over- expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1). {ECO:0000269|PubMed:12821938, ECO:0000269|PubMed:17603038, ECO:0000269|PubMed:18541147, ECO:0000269|PubMed:21460850}.
Subcellular Location Cytoplasm {ECO:0000250}.

TXNIP (D5F3E) Rabbit mAb - 14715 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D5F3E
Western blot analysis of extracts from various cell lines using TXNIP (D5F3E) Rabbit mAb.

VDUP1 (H-12) - sc-271238 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
VDUP1 (H-12): sc-271238. Western blot analysis of VDUP1 expression in non-transfected: sc-117752 (A) and mouse VDUP1 transfected: sc-124550 (B) 293T whole cell lysates.

VDUP1 (H-115) - sc-67134 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
VDUP1 (H-115): sc-67134. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear and membrane localization.

VDUP1 (D-2) - sc-271237 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
VDUP1 (D-2): sc-271237. Western blot analysis of VDUP1 expression in non-transfected: sc-117752 (A) and mouse VDUP1 transfected: sc-124550 (B) 293T whole cell lysates.

VDUP1 (D-15)-R - sc-33098-R from Santa Cruz Biotechnology

Prices $61.00
Sizes 100 µg/0.5 ml
Host Rabbit
Clonality Polyclonal
VDUP1 (D-15): sc-33098. Western blot analysis of VDUP1 expression in NK-92 (A) and M1 (B) whole cell lysates.

VDUP1 (B-2) - sc-166234 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
VDUP1 (B-2): sc-166234. Western blot analysis of VDUP1 expression in non-transfected: sc-117752 (A) and mouse VDUP1 transfected: sc-124550 (B) 293T whole cell lysates.

VDUP1 (C-18) - sc-33099 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
VDUP1 (C-18): sc-33099. Western blot analysis of VDUP1 expression in HL-60 whole cell lysate.

Anti-TXNIP antibody - ab86983 from Abcam

Prices $394.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TXNIP antibody (ab86983) at 1 µg/mlLane 1 : Kidney (Human) Tissue Lysate - adult normal tissue (ab30203)Lane 2 : Thymus (Human) Tissue Lysate - adult normal tissue (ab30146)Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-TXNIP antibody - ab114981 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Detection of TXNIP in Immunoprecipitates of HeLa whole cell lysate (1 mg for IP, 20% of IP loaded) using ab114981 at 6 µg/mg lysate for IP and at 1 µg/ml for subsequent Western blot detection. Detection: Chemiluminescence with an exposure time of 10 seconds.

Anti-TXNIP antibody [EPR14774] - ab188865 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR14774
Flow cytometric analysis of 2% paraformaldehyde-fixed HeLa cells labeling TXNIP with ab188865 at 1/200 dilution (red) compared to a Rabbit monoclonal IgG isotype control (green), followed by Goat anti rabbit IgG (FITC) secondary antibody at 1/150 dilution.

Anti-TXNIP antibody - N-terminal - ab156086 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-TXNIP antibody - N-terminal (ab156086) at 1/100 dilution + NCI-H292 cell line lysate at 35 µg

Anti-TXNIP Antibody (aa116-145, Azide-free, HRP) - LS-C224551 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TXNIP Antibody (aa116-145, FITC) - LS-C224550 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TXNIP Antibody (aa1-30) - LS-C157006 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
TXNIP Antibody western blot of NCI-H292 cell line lysates (35 ug/lane). The TXNIP antibody detected the TXNIP protein (arrow).

Anti-TXNIP Antibody (aa116-145) - LS-C157966 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Mouse Txnip Antibody western blot of mouse stomach tissue lysates (35 ug/lane). The Mouse Txnip antibody detected the Mouse Txnip protein (arrow).

Anti-TXNIP Antibody (aa1-30, AP) - LS-C224552 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TXNIP Antibody (aa116-145, PE) - LS-C224553 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TXNIP Antibody (aa1-30, APC) - LS-C224554 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TXNIP Antibody (aa1-30, Biotin) - LS-C224555 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TXNIP Antibody (aa65-114) - LS-C201729 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human Jurkat. TXNIP antibody dilution 1.0 ug/ml.

Anti-TXNIP Antibody (aa1-30, FITC) - LS-C224556 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TXNIP Antibody (clone JY1) - LS-C179728 from LifeSpan Bioscience

Prices $380.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone JY1

Anti-TXNIP Antibody (aa1-30, Azide-free, HRP) - LS-C224558 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TXNIP Antibody (aa1-30, PE) - LS-C224559 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TXNIP Antibody (aa116-145) - LS-C326110 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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