CHMP4C

Gene Symbol	CHMP4C
Entrez Gene	92421
Alt Symbol	SNF7-3, Shax3, VPS32C
Species	Human
Gene Type	protein-coding
Description	charged multivesicular body protein 4C
Other Description	SNF7 homolog associated with Alix 3|Snf7 homologue associated with Alix 3|charged multivesicular body protein 4c|chromatin modifying protein 4C|chromatin-modifying protein 4c|hSnf7-3|hVps32-3|vacuolar protein sorting-associated protein 32-3|vps32-3
Swissprots	B2RBZ1 Q96CF2
Accessions	EAW87107 Q96CF2 AB120734 BAC87888 AK000049 AK314873 BAG37388 AY329086 AAQ91195 BC014321 AAH14321 BQ778244 BX492886 NM_152284 NP_689497
Function	Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature r
Subcellular Location	Cytoplasm, cytosol. Late endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Midbody. Note=Localizes to the midbody during cytokinesis. Phosphorylation at Ser-210 by AURKB triggers localization to Flemming body (PubMed:22422861). {ECO:0000269|PubMed:22422861}.
Tissue Specificity	Expressed in heart, spleen and kidney. {ECO:0000269|PubMed:14583093, ECO:0000269|PubMed:14678797}.
Top Pathways	Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CHMP4C (E-12) - sc-82560 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

CHMP4C (Q-16) - sc-82561 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-CHMP4C antibody - ab155668 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-CHMP4C antibody - ab168205 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-CHMP4C antibody - C-terminal - ab174798 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-CHMP4C Antibody - LS-C306950 from LifeSpan Bioscience Prices $455.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-CHMP4C Antibody (C-Terminus) - LS-C340669 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-CHMP4C Antibody (aa146-195) - LS-C170431 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

CHMP4C Antibody - NBP2-15888 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CHMP4C Antibody - NBP1-81166 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CHMP4C Antibody - H00092421-B01P from Novus Biologicals Prices $359.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-CHMP4C antibody produced in rabbit - HPA023799 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-CHMP4C antibody produced in mouse - SAB1408191 from Sigma-Aldrich Prices $347.00 Sizes 50 µg Host Mouse Clonality Polyclonal

CHMP4C antibody - GTX122876 from GeneTex Prices $119.00 Sizes 25 μl Host Rabbit Clonality Polyclonal

Anti -CHMP4C (Charged Multivesicular Body Protein 4C, Chromatin-modifying Protein 4c,CHMP4c, SNF7 Homolog Associated with Alix 3, SNF7-3, hSnf7-3, Vacuolar ProteinSorting-associated Protein 32-3, Vps32-3, hVps32-3, SHAX3, MGC22825) - 124960 from USBiological Life Science Host Mouse Clonality Polyclonal

CHMP4C antibody - H00092421-B01P from Acris Antibodies Prices $360.00 Sizes 50 µg Host Mouse Clonality Polyclonal

CHMP4C antibody - 16256-1-AP from Proteintech Group Host Rabbit Clonality Polyclonal

CHMP4C, Polyclonal Antibody - MBS2525016 from MyBioSource Prices $195.00, $270.00, $435.00 Sizes 60 µl, 120 µl, 200 µl Host Rabbit Clonality Polyclonal

CHMP4C - MBS275318 from MyBioSource Prices $360.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CHMP4C Antibody - EPP11520 from Elabscience Prices $296.00, $485.00 Sizes 120 μl, 200 μl Host Rabbit Clonality Polyclonal

Anti-CHMP4C (aa 1-168) polyclonal antibody - DPABH-05284 from Creative Diagnostics Host Rabbit Clonality Polyclonal

Anti-CHMP4C (full length) polyclonal antibody - DPABH-06953 from Creative Diagnostics Host Mouse Clonality Polyclonal

Anti-CHMP4C monoclonal antibody - DCABH-200369 from Creative Diagnostics Host Rabbit Clonality Monoclonal

CHMP4C Polyclonal Antibody - PA5-32050 from Thermo Fisher Scientific Prices $349.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CHMP4C (N) Antibody, Rabbit Polyclonal - R3257-1 from Abiocode Prices $279.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

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