CHMP4C

Gene Symbol CHMP4C
Entrez Gene 92421
Alt Symbol SNF7-3, Shax3, VPS32C
Species Human
Gene Type protein-coding
Description charged multivesicular body protein 4C
Other Description SNF7 homolog associated with Alix 3|Snf7 homologue associated with Alix 3|charged multivesicular body protein 4c|chromatin modifying protein 4C|chromatin-modifying protein 4c|hSnf7-3|hVps32-3|vacuolar protein sorting-associated protein 32-3|vps32-3
Swissprots B2RBZ1 Q96CF2
Accessions EAW87107 Q96CF2 AB120734 BAC87888 AK000049 AK314873 BAG37388 AY329086 AAQ91195 BC014321 AAH14321 BQ778244 BX492886 NM_152284 NP_689497
Function Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature r
Subcellular Location Cytoplasm, cytosol. Late endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Midbody. Note=Localizes to the midbody during cytokinesis. Phosphorylation at Ser-210 by AURKB triggers localization to Flemming body (PubMed:22422861). {ECO:0000269|PubMed:22422861}.
Tissue Specificity Expressed in heart, spleen and kidney. {ECO:0000269|PubMed:14583093, ECO:0000269|PubMed:14678797}.
Top Pathways Endocytosis

CHMP4C Antibody Blocking Peptide - LS-E24154 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

CHMP4C fusion protein - Ag9577 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PET28a
Species Human

CHMP4C fusion protein - Ag9279 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PGEX-4T
Species Human

Recombinant Human CHMP4C, His-tagged - CHMP4C-11188H from Creative Biomart

Category Protein
Source E.coli
Species Human

Recombinant Human Charged multivesicular body protein 4c(CHMP4C) - CSB-YP853396HU CSB-EP853396HU CSB-BP853396HU CSB-MP853396HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

CHMP4C - TP304802 from Acris Antibodies

Category Protein
Prices $680.00
Sizes 20 µg
Source HEK293 cells
Species Human
CHMP4C

CHMP4C Recombinant Protein Antigen - NBP1-81166PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

CHMP4C Peptide, Human - M34GP03107H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

Charged multivesicular body protein 4c (CHMP4C), Recombinant Protein - MBS1321110 from MyBioSource

Category Protein
Prices $985.00, $985.00, $1,210.00, $1,210.00, $1,495.00, $1,495.00, $1,955.00, $1,955.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 50 µg (Mammalian-Cell), 500 µg (Yeast), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human
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