CHMP4C

Gene Symbol	CHMP4C
Entrez Gene	92421
Alt Symbol	SNF7-3, Shax3, VPS32C
Species	Human
Gene Type	protein-coding
Description	charged multivesicular body protein 4C
Other Description	SNF7 homolog associated with Alix 3|Snf7 homologue associated with Alix 3|charged multivesicular body protein 4c|chromatin modifying protein 4C|chromatin-modifying protein 4c|hSnf7-3|hVps32-3|vacuolar protein sorting-associated protein 32-3|vps32-3
Swissprots	B2RBZ1 Q96CF2
Accessions	EAW87107 Q96CF2 AB120734 BAC87888 AK000049 AK314873 BAG37388 AY329086 AAQ91195 BC014321 AAH14321 BQ778244 BX492886 NM_152284 NP_689497
Function	Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature r
Subcellular Location	Cytoplasm, cytosol. Late endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Midbody. Note=Localizes to the midbody during cytokinesis. Phosphorylation at Ser-210 by AURKB triggers localization to Flemming body (PubMed:22422861). {ECO:0000269|PubMed:22422861}.
Tissue Specificity	Expressed in heart, spleen and kidney. {ECO:0000269|PubMed:14583093, ECO:0000269|PubMed:14678797}.
Top Pathways	Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CHMP4C-Over-expression-Lysate - LY13768a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

CHMP4C 293T Cell Transient Overexpression Lysate(Denatured) - H00092421-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

CHMP4C overexpression lysate - LY407666 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

CHMP4C 293 Cell Lysate - 404328 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

CHMP4C Overexpression Lysate (Native) - NBL1-09161 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

CHMP4C Over-expression Lysate Product - GWB-334C8B from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

CHMP4C Overexpression Lysate (Denatured) - H00092421-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

CHMP4C Overexpression Lysate (Denatured) - H00092421-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

CHMP4C knockout Cell lysate - LC810593 from Acris Antibodies Category Cell Lysate Prices $495.00 Sizes 100 µg

Panoply™ Human CHMP4C Knockdown Stable Cell Line - CSC-DC003107 from Creative biogene Category Cell Line Species Human

Human CHMP4C Knockout Cell Line-HeLa - CSC-RT0893 from Creative biogene Category Cell Line Species Human

CHMP4C KO Cell Lysate-HeLa - CLKO-0386 from Creative biogene Category Cell Lysate

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