| Gene Symbol | CHMP4C |
|---|---|
| Entrez Gene | 92421 |
| Alt Symbol | SNF7-3, Shax3, VPS32C |
| Species | Human |
| Gene Type | protein-coding |
| Description | charged multivesicular body protein 4C |
| Other Description | SNF7 homolog associated with Alix 3|Snf7 homologue associated with Alix 3|charged multivesicular body protein 4c|chromatin modifying protein 4C|chromatin-modifying protein 4c|hSnf7-3|hVps32-3|vacuolar protein sorting-associated protein 32-3|vps32-3 |
| Swissprots | B2RBZ1 Q96CF2 |
| Accessions | EAW87107 Q96CF2 AB120734 BAC87888 AK000049 AK314873 BAG37388 AY329086 AAQ91195 BC014321 AAH14321 BQ778244 BX492886 NM_152284 NP_689497 |
| Function | Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature r |
| Subcellular Location | Cytoplasm, cytosol. Late endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Midbody. Note=Localizes to the midbody during cytokinesis. Phosphorylation at Ser-210 by AURKB triggers localization to Flemming body (PubMed:22422861). {ECO:0000269|PubMed:22422861}. |
| Tissue Specificity | Expressed in heart, spleen and kidney. {ECO:0000269|PubMed:14583093, ECO:0000269|PubMed:14678797}. |
| Top Pathways | Endocytosis |