| Gene Symbol | CHMP4C |
|---|---|
| Entrez Gene | 92421 |
| Alt Symbol | SNF7-3, Shax3, VPS32C |
| Species | Human |
| Gene Type | protein-coding |
| Description | charged multivesicular body protein 4C |
| Other Description | SNF7 homolog associated with Alix 3|Snf7 homologue associated with Alix 3|charged multivesicular body protein 4c|chromatin modifying protein 4C|chromatin-modifying protein 4c|hSnf7-3|hVps32-3|vacuolar protein sorting-associated protein 32-3|vps32-3 |
| Swissprots | B2RBZ1 Q96CF2 |
| Accessions | EAW87107 Q96CF2 AB120734 BAC87888 AK000049 AK314873 BAG37388 AY329086 AAQ91195 BC014321 AAH14321 BQ778244 BX492886 NM_152284 NP_689497 |
| Function | Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature r |
| Subcellular Location | Cytoplasm, cytosol. Late endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Midbody. Note=Localizes to the midbody during cytokinesis. Phosphorylation at Ser-210 by AURKB triggers localization to Flemming body (PubMed:22422861). {ECO:0000269|PubMed:22422861}. |
| Tissue Specificity | Expressed in heart, spleen and kidney. {ECO:0000269|PubMed:14583093, ECO:0000269|PubMed:14678797}. |
| Top Pathways | Endocytosis |
CHMP4C CRISPR/Cas9 KO Plasmid (h) - sc-404325 from Santa Cruz Biotechnology
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CHMP4C HDR Plasmid (h) - sc-404325-HDR from Santa Cruz Biotechnology
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CHMP4C Double Nickase Plasmid (h) - sc-404325-NIC from Santa Cruz Biotechnology
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CHMP4C Double Nickase Plasmid (h2) - sc-404325-NIC-2 from Santa Cruz Biotechnology
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CHMP4C CRISPR Activation Plasmid (h) - sc-404325-ACT from Santa Cruz Biotechnology
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CHMP4C CRISPR Activation Plasmid (h2) - sc-404325-ACT-2 from Santa Cruz Biotechnology
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CHMP4C Lentiviral Activation Particles (h) - sc-404325-LAC from Santa Cruz Biotechnology
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CHMP4C Lentiviral Activation Particles (h2) - sc-404325-LAC-2 from Santa Cruz Biotechnology
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CHMP4C siRNA (h) - sc-72899 from Santa Cruz Biotechnology
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CHMP4C shRNA Plasmid (h) - sc-72899-SH from Santa Cruz Biotechnology
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CHMP4C shRNA (h) Lentiviral Particles - sc-72899-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU008321 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6074 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6074 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07996 from Sigma-Aldrich
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CHMP4C siRNA (Human) - CRJ4141 from Cohesion Biosciences
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CHMP4C - MBS8218628 from MyBioSource
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shRNA set against Human CHMP4C (NM_152284.3) - SHH263229 from Creative biogene
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shRNA set against Human CHMP4C(NM_152284.3) - SHG175839 from Creative biogene
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Human CHMP4C siRNA - orb274642 from Biorbyt
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CHMP4C shRNA Plasmid (Human) - CHJ4141 from Cohesion Biosciences
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CHMP4C miRNA 3'UTR clone - MiUTR1H-02125 from Creative biogene
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