ADM

Gene Symbol ADM
Entrez Gene 133
Alt Symbol AM, PAMP
Species Human
Gene Type protein-coding
Description adrenomedullin
Other Description preproadrenomedullin|proadrenomedullin N-20 terminal peptide
Swissprots Q6FGW2 D3DQV3 P35318 B2R793
Accessions AAC60642 AAZ38717 BAA07756 CBX47636 EAW68571 EAW68572 P35318 AK312893 BAG35740 BC015961 AAH15961 BQ021632 BT006902 AAP35548 CR541995 CAG46792 D14874 BAA03589 HY105655 NM_001124 NP_001115
Function AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.
Subcellular Location Secreted.
Tissue Specificity Highest levels found in pheochromocytoma and adrenal medulla. Also found in lung, ventricle and kidney tissues.

ADM (C-20) - sc-16496 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ADM (C-20): sc-16496. Western blot analysis of human recombinant ADM.

ADM (F-20) - sc-16495 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

ADM (FL-185) - sc-33187 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ADM (FL-185): sc-33187. Western blot analysis of human mature ADM purified protein.

ADM (HTA91a/G2) - sc-53154 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

ADM (HTA171/E8) - sc-53153 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ADM (HTA171/E8): sc-53153. Immunoperoxidase staining of formalin fixed, paraffin-embedded human stomach tissue showing cytoplasmic staining of glandular cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

ADM (027-01-1) - sc-80462 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
ADM (027-01-1): sc-80462. Western blot analysis of human recombinant ADM.

Anti-Adrenomedullin antibody - ab69117 from Abcam

Prices $388.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Adrenomedullin antibody (ab69117) at 1 µg/mlLane 1 : Breast (Human) Tissue Lysate - normal tissue (ab30090)Lane 2 : MCF7 (Human breast adenocarcinoma cell line) Whole Cell LysateLane 3 : DU 145 (Human prostate carcinoma cell line) Whole Cell LysateLane 4 : MDA-MB-361 (Human breast adenocarcinoma cell line) Whole Cell LysateLysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutionPerformed under reducing conditions.

Anti-Adrenomedullin antibody - ab190819 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Adrenomedullin antibody (ab190819) at 1/500 dilution + Mouse kidney extract at 30 µg

Anti-Adrenomedullin antibody - ab125409 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Adrenomedullin antibody (ab125409) at 1 µg/ml + HepG2 cell lysate at 10 µg

Anti-Adrenomedullin antibody [HTA171/E8] - ab18092 from Abcam

Prices $382.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone HTA171/E8
Overlay histogram showing PC12 cells stained with ab18092 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab18092, 1µg/1x106 cells) for 30 min at 22ºC. The secondary antibody used was DyLight® 488 goat anti-mouse IgM (mu chain) (ab97007) at 1/500 dilution for 30 min at 22ºC. Isotype control antibody (black line) was mouse IgM [ICIGM] (ab91545, 2µg/1x106 cells) used under the same conditions. Acquisition of >5,000 events was performed.

Anti-Adrenomedullin antibody [HTA91a/G2] - ab18093 from Abcam

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone HTA91a/G2

Anti-ADM / Adrenomedullin Antibody - LS-C183741 from LifeSpan Bioscience

Prices $605.00
Sizes 400 µg
Host Rabbit
Clonality Polyclonal

Anti-ADM / Adrenomedullin Antibody (C-Terminus) - LS-C146416 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ADM / Adrenomedullin antibody LS-C146416 Western blot of HepG2 Cell lysate. Antibody concentration 1 ug/ml.

Anti-ADM / Adrenomedullin Antibody - LS-C183742 from LifeSpan Bioscience

Prices $605.00
Sizes 400 µg
Host Rabbit
Clonality Polyclonal

Anti-ADM / Adrenomedullin Antibody (clone GF1) - LS-C189927 from LifeSpan Bioscience

Prices $800.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal
Clone GF1

Anti-ADM / Adrenomedullin Antibody (aa1-44) - LS-C190453 from LifeSpan Bioscience

Prices $635.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ADM / Adrenomedullin Antibody (aa1-52) - LS-C190454 from LifeSpan Bioscience

Prices $635.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-ADM / Adrenomedullin Antibody (aa153-185) - LS-C190455 from LifeSpan Bioscience

Prices $635.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-ADM / Adrenomedullin Antibody (aa1-52) - LS-C190456 from LifeSpan Bioscience

Prices $635.00
Sizes 400 µg
Host Rabbit
Clonality Polyclonal

Anti-ADM / Adrenomedullin Antibody (Asn100) - LS-C177513 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of ADM (N100) pAb in paraffin-embedded human brain tissue.

Anti-ADM / Adrenomedullin Antibody (aa153-185) - LS-C190457 from LifeSpan Bioscience

Prices $635.00
Sizes 400 µg
Host Rabbit
Clonality Polyclonal

Anti-ADM / Adrenomedullin Antibody (aa45-92) - LS-C190458 from LifeSpan Bioscience

Prices $635.00
Sizes 400 µg
Host Rabbit
Clonality Polyclonal

Anti-ADM / Adrenomedullin Antibody - LS-C190460 from LifeSpan Bioscience

Prices $605.00
Sizes 400 µg
Host Rabbit
Clonality Polyclonal

Anti-ADM / Adrenomedullin Antibody - LS-C190459 from LifeSpan Bioscience

Prices $605.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-ADM / Adrenomedullin Antibody (aa22-147, clone TS106) - LS-C191419 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone TS106
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