| Gene Symbol |
ADM
|
| Entrez Gene |
133
|
| Alt Symbol |
AM, PAMP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
adrenomedullin
|
| Other Description |
preproadrenomedullin|proadrenomedullin N-20 terminal peptide
|
| Swissprots |
Q6FGW2 D3DQV3 P35318 B2R793
|
| Accessions |
AAC60642 AAZ38717 BAA07756 CBX47636 EAW68571 EAW68572 P35318 AK312893 BAG35740 BC015961 AAH15961 BQ021632 BT006902 AAP35548 CR541995 CAG46792 D14874 BAA03589 HY105655 NM_001124 NP_001115
|
| Function |
AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.
|
| Subcellular Location |
Secreted.
|
| Tissue Specificity |
Highest levels found in pheochromocytoma and adrenal medulla. Also found in lung, ventricle and kidney tissues.
|