| Gene Symbol |
GALNT15
|
| Entrez Gene |
117248
|
| Alt Symbol |
GALNACT15, GALNT13, GALNT7, GALNTL2, PIH5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
polypeptide N-acetylgalactosaminyltransferase 15
|
| Other Description |
UDP-GalNAc transferase T15|UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 2|UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15|UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7|UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 2|galNAc-T-like protein 2|polypeptide GalNAc transferase 15|polypeptide GalNAc transferase-like protein 2|polypeptide N-acetylgalactosaminyltransferase 13|polypeptide N-acetylgalactosaminyltransferase-like protein 2|pp-GaNTase-like protein 2|pp-GalNAc-T15|pregnancy-induced hypertension syndrome-related protein 5|protein-UDP acetylgalactosaminyltransferase-like protein 2
|
| Swissprots |
Q86T60 Q96C46 F1LIP6 B2R638 Q8N3T1 A6NMN1 Q96DJ5
|
| Accessions |
CAG32963 CAK32357 EAW64266 EAW64267 Q8N3T1 AB078149 BAD29961 AF361251 AAK48940 AJ505964 CAD44542 AK094780 BAG52928 AK225673 AK312425 BAG35335 AL831925 CAD38585 AL832575 CAD89983 AL832736 AM392821 CAL37699 AM393321 CAL38199 AY035399 AAK63127 AY358443 AAQ88808 BC014789 AAH14789 BC030625 AAH30625 DQ891053 ABM81979 DQ894232 ABM85158 XM_005264851 XP_005264908 XM_005264852 XP_005264909 NM_054110 NP_473451
|
| Function |
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Although it displays a much weaker activity toward all substrates tested compared to GALNT2, it is able to transfer up to seven GalNAc residues to the Muc5AC peptide, suggesting that it can fill vicinal Thr/Ser residues in cooperation with other GALNT proteins. Prefers Muc1a as substrate.
|
| Subcellular Location |
Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed. Highly expressed in small intestine, placenta, spleen, cerebral cortex and ovary. Expressed at intermediate level in uterus, mammary gland, stomach, cerebellum and whole brain. Weakly expressed in fetal brain, bone marrow, thyroid gland, thymus, heart, skeletal muscle, lung, liver, colon, pancreas, kidney and testis. Not expressed in leukocyte. Expressed in both normal and osteoarthritic cartilage. Expressed at low level in chondrocytes in all zones of both normal and osteoarthritic cartilage. {ECO:0000269|PubMed:11597177, ECO:0000269|PubMed:15147861}.
|
| Top Pathways |
Mucin type O-Glycan biosynthesis
|