GALNT15

Gene Symbol GALNT15
Entrez Gene 117248
Alt Symbol GALNACT15, GALNT13, GALNT7, GALNTL2, PIH5
Species Human
Gene Type protein-coding
Description polypeptide N-acetylgalactosaminyltransferase 15
Other Description UDP-GalNAc transferase T15|UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 2|UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15|UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7|UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 2|galNAc-T-like protein 2|polypeptide GalNAc transferase 15|polypeptide GalNAc transferase-like protein 2|polypeptide N-acetylgalactosaminyltransferase 13|polypeptide N-acetylgalactosaminyltransferase-like protein 2|pp-GaNTase-like protein 2|pp-GalNAc-T15|pregnancy-induced hypertension syndrome-related protein 5|protein-UDP acetylgalactosaminyltransferase-like protein 2
Swissprots Q86T60 Q96C46 F1LIP6 B2R638 Q8N3T1 A6NMN1 Q96DJ5
Accessions CAG32963 CAK32357 EAW64266 EAW64267 Q8N3T1 AB078149 BAD29961 AF361251 AAK48940 AJ505964 CAD44542 AK094780 BAG52928 AK225673 AK312425 BAG35335 AL831925 CAD38585 AL832575 CAD89983 AL832736 AM392821 CAL37699 AM393321 CAL38199 AY035399 AAK63127 AY358443 AAQ88808 BC014789 AAH14789 BC030625 AAH30625 DQ891053 ABM81979 DQ894232 ABM85158 XM_005264851 XP_005264908 XM_005264852 XP_005264909 NM_054110 NP_473451
Function Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Although it displays a much weaker activity toward all substrates tested compared to GALNT2, it is able to transfer up to seven GalNAc residues to the Muc5AC peptide, suggesting that it can fill vicinal Thr/Ser residues in cooperation with other GALNT proteins. Prefers Muc1a as substrate.
Subcellular Location Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Tissue Specificity Widely expressed. Highly expressed in small intestine, placenta, spleen, cerebral cortex and ovary. Expressed at intermediate level in uterus, mammary gland, stomach, cerebellum and whole brain. Weakly expressed in fetal brain, bone marrow, thyroid gland, thymus, heart, skeletal muscle, lung, liver, colon, pancreas, kidney and testis. Not expressed in leukocyte. Expressed in both normal and osteoarthritic cartilage. Expressed at low level in chondrocytes in all zones of both normal and osteoarthritic cartilage. {ECO:0000269|PubMed:11597177, ECO:0000269|PubMed:15147861}.
Top Pathways Mucin type O-Glycan biosynthesis

GalNAc-TL2 CRISPR/Cas9 KO Plasmid (h) - sc-414112 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GalNAc-TL2 HDR Plasmid (h) - sc-414112-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GalNAc-TL2 Double Nickase Plasmid (h) - sc-414112-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GalNAc-TL2 Double Nickase Plasmid (h2) - sc-414112-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GalNAc-TL2 CRISPR Activation Plasmid (h) - sc-414112-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GalNAc-TL2 CRISPR Activation Plasmid (h2) - sc-414112-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GalNAc-TL2 Lentiviral Activation Particles (h) - sc-414112-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GalNAc-TL2 Lentiviral Activation Particles (h2) - sc-414112-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GalNAc-TL2 siRNA (h) - sc-78461 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GalNAc-TL2 shRNA Plasmid (h) - sc-78461-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GalNAc-TL2 shRNA (h) Lentiviral Particles - sc-78461-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GALNT13 RNAi - H00114805-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Polypeptide GalNac Transferase 7/GALNT7 RNAi - H00051809-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU075941 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN9116 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08394 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr08394

GALNT15 siRNA (Human) - CRJ4565 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

GALNT15 - MBS8230498 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human GALNTL2 (NM_054110.4) - SHH299125 from Creative biogene

Category siRNA
Species Reactivities Human

Human GALNT15 siRNA - orb275066 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

GALNT15 shRNA Plasmid (Human) - CHJ4565 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

GALNTL2 miRNA 3'UTR clone - MiUTR4H-TG03725 from Creative biogene

Species Reactivities Human
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