FRS2

Gene Symbol FRS2
Entrez Gene 10818
Alt Symbol FRS2A, FRS2alpha, SNT, SNT-1, SNT1
Species Human
Gene Type protein-coding
Description fibroblast growth factor receptor substrate 2
Other Description FGFR signalling adaptor|FGFR substrate 2|FGFR-signaling adaptor SNT|suc1-associated neurotrophic factor target 1
Swissprots Q7LDQ6 O43558 B0LPF2 B2R684 Q8WU20
Accessions ABY87531 AGC09590 EAW97225 EAW97226 EAW97227 Q8WU20 AF036717 AAB92554 AK226068 AK312477 BAG35381 BC021562 AAH21562 BP217337 BP230333 BP280775 BP311537 BP363404 BU166503 BX647520 BX647544 CD677411 DA189114 DA311708 DA721439 DA762876 DB081843 DR003634 JF432165 ADZ15382 NM_001042555 NP_001036020 NM_001278351 NP_001265280 NM_001278353 NP_001265282 NM_001278354 NP_001265283 NM_001278355 NP_001265284 NM_001278356 NP_001265285 NM_001278357 NP_001265286 NM_006654 NP_006645
Function Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3- kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. {ECO:0000269|PubMed:12974390, ECO:0000269|PubMed:21765395}.
Subcellular Location Endomembrane system. Note=Cytoplasmic, membrane-bound.
Tissue Specificity Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. {ECO:0000269|PubMed:10092678}.
Top Pathways Neurotrophin signaling pathway, Proteoglycans in cancer

FRS2-Over-expression-Lysate - LY14936a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag FRS2 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the FRS2 gene.

FRS2 293T Cell Transient Overexpression Lysate(Denatured) - H00010818-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

FRS2 293 Cell Lysate - 401769 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

FRS2 Overexpression Lysate (Denatured) - H00010818-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl
Lane 1: FRS2 transfected lysate (57.5 KDa) Lane 2: Non-transfected lysate.

FRS2 Overexpression Lysate (Native) - NBP2-08387 from Novus Biologicals

Category Cell Lysate
Prices $529.00
Sizes 100 µg

FRS2 Overexpression Lysate (Native) - NBP2-09242 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg

FRS2 Overexpression Lysate (Native) - NBL1-10836 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: FRS2 Overexpression Lysate (Adult Normal) [NBL1-10836] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for FRS2.

FRS2 Over-expression Lysate Product - GWB-6E61E8 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

Panoply™ Human FRS2 Knockdown Stable Cell Line - CSC-DC005915 from Creative biogene

Category Cell Line
Species Human
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