FRS2

Gene Symbol	FRS2
Entrez Gene	10818
Alt Symbol	FRS2A, FRS2alpha, SNT, SNT-1, SNT1
Species	Human
Gene Type	protein-coding
Description	fibroblast growth factor receptor substrate 2
Other Description	FGFR signalling adaptor|FGFR substrate 2|FGFR-signaling adaptor SNT|suc1-associated neurotrophic factor target 1
Swissprots	Q7LDQ6 O43558 B0LPF2 B2R684 Q8WU20
Accessions	ABY87531 AGC09590 EAW97225 EAW97226 EAW97227 Q8WU20 AF036717 AAB92554 AK226068 AK312477 BAG35381 BC021562 AAH21562 BP217337 BP230333 BP280775 BP311537 BP363404 BU166503 BX647520 BX647544 CD677411 DA189114 DA311708 DA721439 DA762876 DB081843 DR003634 JF432165 ADZ15382 NM_001042555 NP_001036020 NM_001278351 NP_001265280 NM_001278353 NP_001265282 NM_001278354 NP_001265283 NM_001278355 NP_001265284 NM_001278356 NP_001265285 NM_001278357 NP_001265286 NM_006654 NP_006645
Function	Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3- kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. {ECO:0000269|PubMed:12974390, ECO:0000269|PubMed:21765395}.
Subcellular Location	Endomembrane system. Note=Cytoplasmic, membrane-bound.
Tissue Specificity	Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. {ECO:0000269|PubMed:10092678}.
Top Pathways	Neurotrophin signaling pathway, Proteoglycans in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human FRS2 full length protein - ab132038 from Abcam Category Protein Source Wheat germ Species Human

Human FRS2 peptide - ab86243 from Abcam Category Peptide

Human FRS2 protein fragment - ab112397 from Abcam Category Protein Source Wheat germ Species Human

FRS2 Antibody Blocking Peptide - LS-E6192 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human FRS2 Protein - H00010818-P02 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human FRS2 Protein - H00010818-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

FRS2-Antibody-Center-Blocking-Peptide - BP18833c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

FRS2 Blocking Peptide - 33R-10946 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

SNTA1 protein (His tag) - 80R-2104 from Fitzgerald Category Protein Prices $365.00 Sizes 50 µg Source E.coli

Human FRS2 Protein - abx066619 from Abbexa Category Protein Source E.coli Species Human

FRS2 - H00010818-P02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

FRS2 - H00010818-P02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

FRS2 - H00010818-P02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

FRS2 - H00010818-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

FRS2 - H00010818-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

FRS2 / FGFR substrate 2 - H00010818-P01-10 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Source in vitro transl. Species Human

Fibroblast Growth Factor Receptor Substrate 2 - 20-8317 from ARP American Research Products Category Protein Prices $499.00 Sizes 50 µg Source E.coli Species Human

FRS2 fusion protein - ag19299 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

FRS2 fusion protein - Ag2052 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human FRS2 - FRS2-28951TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Fibroblast Growth Factor Receptor Substrate 2 (FRS2) - RPC063Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Fibroblast Growth Factor Receptor Substrate 2 (FRS2) - RPC063Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Fibroblast Growth Factor Receptor Substrate 2 (FRS2) - RPC063Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

FRS2 (pY436) Blocking Peptide - CBP3944 from Cohesion Biosciences Category Peptide Prices $150.00, $450.00 Sizes 1 mg, 5 mg Species Human, Mouse

Recombinant Fibroblast Growth Factor Receptor Substrate 2 (FRS2) - RPC063Hu01 from Cloud-clone Category Protein Source E.coli Species Human

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