FRS2

Gene Symbol FRS2
Entrez Gene 10818
Alt Symbol FRS2A, FRS2alpha, SNT, SNT-1, SNT1
Species Human
Gene Type protein-coding
Description fibroblast growth factor receptor substrate 2
Other Description FGFR signalling adaptor|FGFR substrate 2|FGFR-signaling adaptor SNT|suc1-associated neurotrophic factor target 1
Swissprots Q7LDQ6 O43558 B0LPF2 B2R684 Q8WU20
Accessions ABY87531 AGC09590 EAW97225 EAW97226 EAW97227 Q8WU20 AF036717 AAB92554 AK226068 AK312477 BAG35381 BC021562 AAH21562 BP217337 BP230333 BP280775 BP311537 BP363404 BU166503 BX647520 BX647544 CD677411 DA189114 DA311708 DA721439 DA762876 DB081843 DR003634 JF432165 ADZ15382 NM_001042555 NP_001036020 NM_001278351 NP_001265280 NM_001278353 NP_001265282 NM_001278354 NP_001265283 NM_001278355 NP_001265284 NM_001278356 NP_001265285 NM_001278357 NP_001265286 NM_006654 NP_006645
Function Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3- kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1. {ECO:0000269|PubMed:12974390, ECO:0000269|PubMed:21765395}.
Subcellular Location Endomembrane system. Note=Cytoplasmic, membrane-bound.
Tissue Specificity Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. {ECO:0000269|PubMed:10092678}.
Top Pathways Neurotrophin signaling pathway, Proteoglycans in cancer

FRS2 CRISPR/Cas9 KO Plasmid (h) - sc-400656 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FRS2 HDR Plasmid (h) - sc-400656-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FRS2 Double Nickase Plasmid (h) - sc-400656-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FRS2 Double Nickase Plasmid (h2) - sc-400656-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FRS2 CRISPR Activation Plasmid (h) - sc-400656-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FRS2 CRISPR Activation Plasmid (h2) - sc-400656-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FRS2 Lentiviral Activation Particles (h) - sc-400656-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FRS2 Lentiviral Activation Particles (h2) - sc-400656-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FRS2 siRNA (h) - sc-35413 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FRS2 shRNA Plasmid (h) - sc-35413-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FRS2 shRNA (h) Lentiviral Particles - sc-35413-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FRS2 RNAi - H00010818-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU004641 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN8955 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8955 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

FRS2 siRNA (Human) - CRH7376 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FRS2 RNAi - H00010818-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

FRS2 - MBS8213984 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human FRS2 (NM_006654.3) - SHH297245 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human FRS2(NM_001042555.1) - SHH068483 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human FRS2(NM_006654.3) - SHH068519 from Creative biogene

Category siRNA
Species Reactivities Human

FRS2 shRNA Plasmid (Human) - CHH7376 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

FRS2 miRNA 3'UTR clone - MiUTR1H-03853 from Creative biogene

Species Reactivities Human

FRS2 miRNA 3'UTR clone - MiUTR1H-03854 from Creative biogene

Species Reactivities Human
Search more