Gene Symbol | MED28 |
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Entrez Gene | 80306 |
Alt Symbol | 1500003D12Rik, EG1, magicin |
Species | Human |
Gene Type | protein-coding |
Description | mediator complex subunit 28 |
Other Description | endothelial-derived gene 1|endothelial-derived protein 1|mediator of RNA polymerase II transcription subunit 28|mediator of RNA polymerase II transcription, subunit 28 homolog|merlin and Grb2-interacting cytoskeletal protein|tumor angiogenesis marker EG-1 |
Swissprots | Q9H204 Q9BZJ5 |
Accessions | EAW92781 EAW92782 Q9H204 AF317678 AF317679 AF317680 AAK11563 AF318059 AAL26906 AF358829 AAK32724 AK313928 BC011936 AAH11936 DQ893391 ABM84317 DQ896713 ABM87712 HY174042 NM_025205 NP_079481 |
Function | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May be part of a complex containing NF2/merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways. {ECO:0000269|PubMed:15467741}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:15467741}. Cytoplasm {ECO:0000269|PubMed:15467741}. Membrane {ECO:0000269|PubMed:15467741}; Peripheral membrane protein {ECO:0000269|PubMed:15467741}. Note=According to PubMed:15467741, it is cytoplasmic and mainly membrane-associated. |
Tissue Specificity | Widely expressed. Highly expressed in vascular tissues such as placenta, testis and liver. {ECO:0000269|PubMed:15467741}. |
Med28 (L-14) - sc-104372 from Santa Cruz Biotechnology
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Anti-MED28 antibody - ab73294 from Abcam
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Anti-MED28 antibody - ab200720 from Abcam
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Anti-MED28 antibody - ab91510 from Abcam
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Anti-MED28 / Magicin Antibody (Internal) IHC-plus⢠- LS-B4987 from LifeSpan Bioscience
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MED28 Antibody - NBP1-85104 from Novus Biologicals
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MED28 Antibody - NBP1-76931 from Novus Biologicals
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MED28 Antibody - NBP2-38271 from Novus Biologicals
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Anti-MED28 antibody produced in rabbit - SAB2900840 from Sigma-Aldrich
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Anti-MED28 antibody produced in rabbit - HPA035900 from Sigma-Aldrich
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Anti-MED28 antibody produced in rabbit - PRS4731 from Sigma-Aldrich
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MED28 antibody - GTX85388 from GeneTex
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MED28 antibody - orb75034 from Biorbyt
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MED28 antibody - 70R-18466 from Fitzgerald
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Anti -MED28 (Mediator of RNA Polymerase II Transcription Subunit 28, Mediator ComplexSubunit 28, Endothelial-derived Protein 1, EG1, FKSG20, Merlin and Grb2-interactingCytoskeletal Protein, Magicin, Tumor Angiogenesis Marker EG-1) - M2847-85A from USBiological Life Science
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Anti -MED28 (Mediator of RNA Polymerase II Transcription Subunit 28, Mediator ComplexSubunit 28, Endothelial-derived Protein 1, EG1, FKSG20, Merlin and Grb2-interactingCytoskeletal Protein, Magicin, Tumor Angiogenesis Marker EG-1, DKFZp434N185, DKFZP434N185) - 146321 from USBiological Life Science
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MED28 Antibody - abx121157 from Abbexa
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MED28 antibody - 16262-1-AP from Acris Antibodies
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MED28 antibody - AP23858PU-N from Acris Antibodies
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MED28 antibody - AP30555PU-N from Acris Antibodies
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MED28 antibody - PAB13054 from Acris Antibodies
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Rabbit Anti-Human MED28 (Internal) - 119-14845 from RayBiotech
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MED28 Antibody - 4731 from ProSci
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MED28 antibody - 16262-1-AP from Proteintech Group
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MED28 Antibody - 253918 from ABBIOTEC
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