Gene Symbol | MED28 |
---|---|
Entrez Gene | 80306 |
Alt Symbol | 1500003D12Rik, EG1, magicin |
Species | Human |
Gene Type | protein-coding |
Description | mediator complex subunit 28 |
Other Description | endothelial-derived gene 1|endothelial-derived protein 1|mediator of RNA polymerase II transcription subunit 28|mediator of RNA polymerase II transcription, subunit 28 homolog|merlin and Grb2-interacting cytoskeletal protein|tumor angiogenesis marker EG-1 |
Swissprots | Q9H204 Q9BZJ5 |
Accessions | EAW92781 EAW92782 Q9H204 AF317678 AF317679 AF317680 AAK11563 AF318059 AAL26906 AF358829 AAK32724 AK313928 BC011936 AAH11936 DQ893391 ABM84317 DQ896713 ABM87712 HY174042 NM_025205 NP_079481 |
Function | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May be part of a complex containing NF2/merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways. {ECO:0000269|PubMed:15467741}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:15467741}. Cytoplasm {ECO:0000269|PubMed:15467741}. Membrane {ECO:0000269|PubMed:15467741}; Peripheral membrane protein {ECO:0000269|PubMed:15467741}. Note=According to PubMed:15467741, it is cytoplasmic and mainly membrane-associated. |
Tissue Specificity | Widely expressed. Highly expressed in vascular tissues such as placenta, testis and liver. {ECO:0000269|PubMed:15467741}. |
MED28 / Magicin Antibody Blocking Peptide - LS-E30543 from LifeSpan Bioscience
|
||||||||||
MED28 Blocking Peptide - NBP1-76931PEP from Novus Biologicals
|
||||||||||
MED28-Antibody-Center-Blocking-peptide - BP12901c from Abgent, a WuXi AppTec company
|
||||||||||
MED28-Antibody-C-term-Blocking-Peptide - BP6873b from Abgent, a WuXi AppTec company
|
||||||||||
MED28 Peptide - GTX85388-PEP from GeneTex
|
||||||||||
MED28 Blocking Peptide - abx161157 from Abbexa
|
||||||||||
MED28 Control Peptide - AP30555CP-N from Acris Antibodies
|
||||||||||
MED28 Peptide - 4731P from ProSci
|
||||||||||
MED28 fusion protein - Ag9230 from Proteintech Group
|
||||||||||
MED28 fusion protein - Ag9327 from Proteintech Group
|
||||||||||
Recombinant Human MED28, His-tagged - MED28-812H from Creative Biomart
|
||||||||||
MED28 Blocking Peptide - CBP3656 from Cohesion Biosciences
|
||||||||||
Recombinant Human Mediator of RNA polymerase II transcription subunit 28(MED28) - CSB-YP863955HU CSB-EP863955HU CSB-BP863955HU CSB-MP863955HU from Cusabio
|
||||||||||
MED28 (full length, N-term HIS tag) - TP760745 from Acris Antibodies
|
||||||||||
MED28 Recombinant Protein Antigen - NBP2-38271PEP from Novus Biologicals
|
||||||||||
MED28 Recombinant Protein Antigen - NBP1-85104PEP from Novus Biologicals
|
||||||||||
MED28 Peptide, Human - M34GP09373H from Creative Peptides
|
||||||||||
Mediator of RNA polymerase II transcription subunit 28 (MED28), Recombinant Protein - MBS1378599 from MyBioSource
|
||||||||||
Mediator of RNA polymerase II transcription subunit 28 (MED28), Recombinant Protein - MBS1429946 from MyBioSource
|
||||||||||
MED28 peptide - orb234531 from Biorbyt
|