| Gene Symbol | MED28 |
|---|---|
| Entrez Gene | 80306 |
| Alt Symbol | 1500003D12Rik, EG1, magicin |
| Species | Human |
| Gene Type | protein-coding |
| Description | mediator complex subunit 28 |
| Other Description | endothelial-derived gene 1|endothelial-derived protein 1|mediator of RNA polymerase II transcription subunit 28|mediator of RNA polymerase II transcription, subunit 28 homolog|merlin and Grb2-interacting cytoskeletal protein|tumor angiogenesis marker EG-1 |
| Swissprots | Q9H204 Q9BZJ5 |
| Accessions | EAW92781 EAW92782 Q9H204 AF317678 AF317679 AF317680 AAK11563 AF318059 AAL26906 AF358829 AAK32724 AK313928 BC011936 AAH11936 DQ893391 ABM84317 DQ896713 ABM87712 HY174042 NM_025205 NP_079481 |
| Function | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May be part of a complex containing NF2/merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways. {ECO:0000269|PubMed:15467741}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:15467741}. Cytoplasm {ECO:0000269|PubMed:15467741}. Membrane {ECO:0000269|PubMed:15467741}; Peripheral membrane protein {ECO:0000269|PubMed:15467741}. Note=According to PubMed:15467741, it is cytoplasmic and mainly membrane-associated. |
| Tissue Specificity | Widely expressed. Highly expressed in vascular tissues such as placenta, testis and liver. {ECO:0000269|PubMed:15467741}. |
Mediator of RNA polymerase II transcription subunit 28 (MED28), Human, ELISA Kit - E01M0081 from ARP American Research Products
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Mediator of RNA polymerase II transcription subunit 28 (MED28), ELISA Kit - MBS7212562 from MyBioSource
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Mediator of RNA polymerase II transcription subunit 28 (MED28), ELISA Kit - MBS7241028 from MyBioSource
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Mediator of RNA polymerase II transcription subunit 28 (MED28), ELISA Kit - MBS7233878 from MyBioSource
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Mediator of RNA polymerase II transcription subunit 28 (MED28), ELISA Kit - MBS7226976 from MyBioSource
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Mediator of RNA polymerase II transcription subunit 28 (MED28), ELISA Kit - MBS7223676 from MyBioSource
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Mediator of RNA polymerase II transcription subunit 28 (MED28), ELISA Kit - MBS7225474 from MyBioSource
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Mediator of RNA polymerase II transcription subunit 28 (MED28), ELISA Kit - MBS7202961 from MyBioSource
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Mediator of RNA polymerase II transcription subunit 28 (MED28), ELISA Kit - MBS7216542 from MyBioSource
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Mediator of RNA polymerase II transcription subunit 28 (MED28), ELISA Kit - MBS7226292 from MyBioSource
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Mediator of RNA polymerase II transcription subunit 28 (MED28), ELISA Kit - MBS7224281 from MyBioSource
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Mediator of RNA polymerase II transcription subunit 28 (MED28), ELISA Kit - MBS7223524 from MyBioSource
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Human MED28 ELISA Kit - E023937 from Biobool
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