| Gene Symbol |
MED28
|
| Entrez Gene |
80306
|
| Alt Symbol |
1500003D12Rik, EG1, magicin
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mediator complex subunit 28
|
| Other Description |
endothelial-derived gene 1|endothelial-derived protein 1|mediator of RNA polymerase II transcription subunit 28|mediator of RNA polymerase II transcription, subunit 28 homolog|merlin and Grb2-interacting cytoskeletal protein|tumor angiogenesis marker EG-1
|
| Swissprots |
Q9H204 Q9BZJ5
|
| Accessions |
EAW92781 EAW92782 Q9H204 AF317678 AF317679 AF317680 AAK11563 AF318059 AAL26906 AF358829 AAK32724 AK313928 BC011936 AAH11936 DQ893391 ABM84317 DQ896713 ABM87712 HY174042 NM_025205 NP_079481
|
| Function |
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May be part of a complex containing NF2/merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways. {ECO:0000269|PubMed:15467741}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:15467741}. Cytoplasm {ECO:0000269|PubMed:15467741}. Membrane {ECO:0000269|PubMed:15467741}; Peripheral membrane protein {ECO:0000269|PubMed:15467741}. Note=According to PubMed:15467741, it is cytoplasmic and mainly membrane-associated.
|
| Tissue Specificity |
Widely expressed. Highly expressed in vascular tissues such as placenta, testis and liver. {ECO:0000269|PubMed:15467741}.
|
![Western Blot: MED28 Overexpression Lysate (Adult Normal) [NBL1-12990] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for MED28.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9512_MED28%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12990-img0002.jpg)