FEN1

Gene Symbol FEN1
Entrez Gene 2237
Alt Symbol FEN-1, MF1, RAD2
Species Human
Gene Type protein-coding
Description flap structure-specific endonuclease 1
Other Description DNase IV|FEN-1|flap endonuclease 1|maturation factor 1|maturation factor-1
Swissprots P39748
Accessions AAB32522 AAC23394 AAM74238 EAW73972 P39748 AK301743 BAG63206 AK312761 BAG35627 BC000323 AAH00323 BM450370 BP244711 BT019524 AAV38331 CN290841 CR536562 CAG38799 L37374 AAA91331 X76771 CAA54166 NM_004111 NP_004102
Function Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double- stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA. {ECO:0000255|HAMAP-Rule:MF_03140, ECO:0000269|PubMed:10744741, ECO:0000269|PubMed:11986308, ECO:0000269|Pub
Subcellular Location Isoform 1: Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
Top Pathways DNA replication, Base excision repair, Non-homologous end-joining

flap structure-specific endonuclease 1, ELISA Kit - MBS9332640 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.1 ng/ml.
Range 0.25 ng/ml- 8 ng/ml.

Human FEN1 ELISA Kit - E015217 from Biobool

Category ELISA Kit
Sensitivity 0.1 ng/ml.

anti-FEN1 antibody - ARG54167 from Arigo Biolaboratories

Category ELISA Kit

anti-FEN1 antibody - ARG54168 from Arigo Biolaboratories

Category ELISA Kit

Flap Endonuclease 1 (FEN1), ELISA Kit - MBS9366543 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Flap Endonuclease 1 (FEN1), ELISA Kit - MBS9346506 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Flap endonuclease 1, ELISA Kit - MBS284270 from MyBioSource

Category ELISA Kit
Prices $465.00, $790.00, $3,500.00, $6,655.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Flap Endonuclease 1 (FEN1), ELISA Kit - MBS9343699 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Flap Endonuclease 1 (FEN1), ELISA Kit - MBS9348762 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Flap Endonuclease 1 (FEN1), ELISA Kit - MBS9365766 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Flap Endonuclease 1 (FEN1), ELISA Kit - MBS9360717 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Flap Endonuclease 1 (FEN1), ELISA Kit - MBS9344522 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Flap Endonuclease 1 (FEN1), ELISA Kit - MBS9365285 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Flap Endonuclease 1 (FEN1), ELISA Kit - MBS9362089 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Flap Endonuclease 1 (FEN1), ELISA Kit - MBS9356081 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Flap Endonuclease 1 (FEN1), ELISA Kit - MBS9348897 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Flap Endonuclease 1 (FEN1), ELISA Kit - MBS9368318 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Flap Endonuclease 1 (FEN1), ELISA Kit - MBS9356563 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Flap Endonuclease 1 (FEN1), ELISA Kit - MBS9366301 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Flap Endonuclease 1 (FEN1), ELISA Kit - MBS9353542 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Flap Endonuclease 1 (FEN1), ELISA Kit - MBS9369520 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Flap Endonuclease 1 (FEN1), ELISA Kit - MBS9375187 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Flap Endonuclease 1 (FEN1), ELISA Kit - MBS9347881 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Flap Endonuclease 1 (FEN1), ELISA Kit - MBS9358685 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
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