| Gene Symbol |
FEN1
|
| Entrez Gene |
2237
|
| Alt Symbol |
FEN-1, MF1, RAD2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
flap structure-specific endonuclease 1
|
| Other Description |
DNase IV|FEN-1|flap endonuclease 1|maturation factor 1|maturation factor-1
|
| Swissprots |
P39748
|
| Accessions |
AAB32522 AAC23394 AAM74238 EAW73972 P39748 AK301743 BAG63206 AK312761 BAG35627 BC000323 AAH00323 BM450370 BP244711 BT019524 AAV38331 CN290841 CR536562 CAG38799 L37374 AAA91331 X76771 CAA54166 NM_004111 NP_004102
|
| Function |
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double- stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA. {ECO:0000255|HAMAP-Rule:MF_03140, ECO:0000269|PubMed:10744741, ECO:0000269|PubMed:11986308, ECO:0000269|Pub
|
| Subcellular Location |
Isoform 1: Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
|
| Top Pathways |
DNA replication, Base excision repair, Non-homologous end-joining
|
![Western Blot: FEN1 Overexpression Lysate (Adult Normal) [NBL1-10676] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for FEN1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2601_FEN1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-10676-img0002.jpg)