FEN1

Gene Symbol	FEN1
Entrez Gene	2237
Alt Symbol	FEN-1, MF1, RAD2
Species	Human
Gene Type	protein-coding
Description	flap structure-specific endonuclease 1
Other Description	DNase IV|FEN-1|flap endonuclease 1|maturation factor 1|maturation factor-1
Swissprots	P39748
Accessions	AAB32522 AAC23394 AAM74238 EAW73972 P39748 AK301743 BAG63206 AK312761 BAG35627 BC000323 AAH00323 BM450370 BP244711 BT019524 AAV38331 CN290841 CR536562 CAG38799 L37374 AAA91331 X76771 CAA54166 NM_004111 NP_004102
Function	Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double- stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA. {ECO:0000255|HAMAP-Rule:MF_03140, ECO:0000269|PubMed:10744741, ECO:0000269|PubMed:11986308, ECO:0000269|Pub
Subcellular Location	Isoform 1: Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.
Top Pathways	DNA replication, Base excision repair, Non-homologous end-joining

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human FEN1 full length protein - ab95382 from Abcam Category Protein Source E. coli Species Human

Human FEN1 peptide - ab73360 from Abcam Category Peptide

Human FEN1 peptide - ab73361 from Abcam Category Peptide

FEN1 Antibody Blocking Peptide - LS-E16803 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FEN1 Antibody Blocking Peptide - LS-E16804 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FEN1 Antibody Blocking Peptide - LS-E7153 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FEN-1 Partial Recombinant Protein - H00002237-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

FEN-1 Recombinant Protein - H00002237-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

Recombinant Human FEN-1 Protein - NBP1-30306 from Novus Biologicals Category Protein Prices $349.00 Sizes 100 µg Species Human

FEN1-Antibody-Center-Blocking-Peptide - BP2856c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

FEN1 Protein (OPPA02024) - OPPA02024 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg

Human Flap Structure-Specific Endonuclease 1 protein - orb90092 from Biorbyt Category Protein Prices $230.00, $442.00 Sizes 5 μg, 20 μg Source E.coli Species Human

Human FEN1 protein - orb49390 from Biorbyt Category Protein Prices $323.00, $485.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

FEN1 Blocking Peptide - 33R-7232 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

FEN1 protein - 30R-1442 from Fitzgerald Category Protein Prices $340.00 Sizes 100 µg Source E.coli

FEN1 Blocking Peptide - abx062611 from Abbexa Category Peptide Species Human, Mouse, Rat, Monkey

FEN1 / RAD2 (1-380) - AR09325PU-L from Acris Antibodies Category Protein Prices $1,020.00 Sizes 500 µg Source E. coli Species Human

FEN1 / RAD2 (1-380) - AR09325PU-N from Acris Antibodies Category Protein Prices $420.00 Sizes 100 µg Source E. coli Species Human

FEN1 / RAD2 - H00002237-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

FEN1 / RAD2 - H00002237-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

FEN1 / RAD2 - H00002237-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Flap Structure-Specific Endonuclease 1, Human Recombinant - 228-12486-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Species Human

Recombinant Human Flap Structure-Specific Endonuclease 1 - 228-12486-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Recombinant Human Flap Structure-Specific Endonuclease 1 - 228-12486-3 from RayBiotech Category Protein Source Escherichia Coli. Species Human

FEN1, 1-380aa, Human, E.coli - 01-1753-1 from ARP American Research Products Category Protein Prices $189.00, $449.00, $1,089.00 Sizes 20 µg, 50 µg, 500 µg Species Human

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