| Gene Symbol | FEN1 |
|---|---|
| Entrez Gene | 2237 |
| Alt Symbol | FEN-1, MF1, RAD2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | flap structure-specific endonuclease 1 |
| Other Description | DNase IV|FEN-1|flap endonuclease 1|maturation factor 1|maturation factor-1 |
| Swissprots | P39748 |
| Accessions | AAB32522 AAC23394 AAM74238 EAW73972 P39748 AK301743 BAG63206 AK312761 BAG35627 BC000323 AAH00323 BM450370 BP244711 BT019524 AAV38331 CN290841 CR536562 CAG38799 L37374 AAA91331 X76771 CAA54166 NM_004111 NP_004102 |
| Function | Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double- stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA. {ECO:0000255|HAMAP-Rule:MF_03140, ECO:0000269|PubMed:10744741, ECO:0000269|PubMed:11986308, ECO:0000269|Pub |
| Subcellular Location | Isoform 1: Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage. |
| Top Pathways | DNA replication, Base excision repair, Non-homologous end-joining |