| Gene Symbol |
TCL1A
|
| Entrez Gene |
8115
|
| Alt Symbol |
TCL1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
T-cell leukemia/lymphoma 1A
|
| Other Description |
T-cell leukemia/lymphoma protein 1A|T-cell lymphoma-1|oncogene TCL-1|oncogene TCL1|protein p14 TCL1
|
| Swissprots |
Q6IBK7 P56279
|
| Accessions |
CDL93495 EAW81622 EAW81623 P56279 BC003574 AAH03574 BC005831 AAH05831 BC009502 BC009891 BC014024 AAH14024 BG718395 BU602054 CR456796 CAG33077 DQ892500 ABM83426 DQ895713 ABM86639 X82240 CAA57708 NM_001098725 NP_001092195 NM_021966 NP_068801 NR_049726
|
| Function |
Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival. {ECO:0000269|PubMed:10716693, ECO:0000269|PubMed:10983986, ECO:0000269|PubMed:11707444, ECO:0000269|PubMed:11839817}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Microsome {ECO:0000269|PubMed:7987816}. Endoplasmic reticulum {ECO:0000269|PubMed:7987816}. Note=Microsomal fraction.
|
| Tissue Specificity |
Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation.
|
| Top Pathways |
PI3K-Akt signaling pathway
|