TCL1A

Gene Symbol TCL1A
Entrez Gene 8115
Alt Symbol TCL1
Species Human
Gene Type protein-coding
Description T-cell leukemia/lymphoma 1A
Other Description T-cell leukemia/lymphoma protein 1A|T-cell lymphoma-1|oncogene TCL-1|oncogene TCL1|protein p14 TCL1
Swissprots Q6IBK7 P56279
Accessions CDL93495 EAW81622 EAW81623 P56279 BC003574 AAH03574 BC005831 AAH05831 BC009502 BC009891 BC014024 AAH14024 BG718395 BU602054 CR456796 CAG33077 DQ892500 ABM83426 DQ895713 ABM86639 X82240 CAA57708 NM_001098725 NP_001092195 NM_021966 NP_068801 NR_049726
Function Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival. {ECO:0000269|PubMed:10716693, ECO:0000269|PubMed:10983986, ECO:0000269|PubMed:11707444, ECO:0000269|PubMed:11839817}.
Subcellular Location Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Microsome {ECO:0000269|PubMed:7987816}. Endoplasmic reticulum {ECO:0000269|PubMed:7987816}. Note=Microsomal fraction.
Tissue Specificity Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation.
Top Pathways PI3K-Akt signaling pathway

TCL1 Antibody - 4042 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from Daudi and Ramos cells using TCL1 Antibody.

TCL1 (1-21) Mouse mAb - 4016 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone 1-21
Western blot analysis of extracts from Ramos, Raji and Daudi cells, using TCL1 (1-21) Mouse mAb.

TCL-1A (A-6) - sc-393436 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TCL-1A (A-6): sc-393436. Western blot analysis of TCL-1A expression in JM1 (A), NAMALWA (B) and Ramos (C) whole cell lysates.

TCL-1A (C-15) - sc-11156 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TCL-1A (C-15): sc-11156. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic, membrane and nuclear localization.

TCL-1A (H-70) - sc-33550 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TCL-1A (H-70): sc-33550. Western blot analysis of TCL-1A expression in NAMALWA whole cell lysate.

TCL-1A (G-16) - sc-11155 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TCL-1A (G-16): sc-11155. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

TCL-1A (1-21) - sc-32331 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TCL-1A (1-21): sc-32331. Immunoperoxidase staining of formalin fixed, paraffin-embedded human lymphoma showing cytoplasmic localization.

Anti-Tcl1 antibody - ab181403 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of rat lung tissue labelling Tcl1 with ab181403 at 1/100. Magnification: 200x.

Anti-Tcl1 antibody - ab88602 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-Tcl1 antibody (ab88602) at 1 µg/ml + Human spleen tissue lysate at 50 µgdeveloped using the ECL technique

Anti-Tcl1 antibody - ab65939 from Abcam

Prices $370.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-Tcl1 antibody (ab65939) at 0.1 µg/ml + Jurkat cell lysate at 35 µg

Anti-Tcl1 antibody - ab32813 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Tcl1 antibody (ab32813) at 1 µg/ml + Ramos (Human Burkitt's lymphoma cell line) Whole Cell Lysate at 10 µgSecondaryIRDye 680 Conjugated Goat Anti-Rabbit IgG (H+L) at 1/10000 dilutionPerformed under reducing conditions.

Anti-Tcl1 antibody - ab37465 from Abcam

Prices $406.00
Sizes 50 µg
Host Chicken
Clonality Polyclonal
Anti-Tcl1 antibody (ab37465) at 1/2000 dilution + E coli-derived fusion proteinSecondaryGoat anti IgY HRP at 1/1000 dilution

Anti-Tcl1 antibody [1-21] - ab91211 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1-21
Staining of Daudi cells with ab91211 at 0.25 µg (blue histogram), or purified Mouse IgG2b, isotype control at 0.25 µg (green histogram), followed by treatment with Biotin anti-Mouse IgG and Phycoerythrin (PE) Streptavidin. Total viable cells were used for analysis.

Anti-Tcl1 antibody [1-21], prediluted (Allophycocyanin) - ab167133 from Abcam

Prices $370.00
Sizes 100 tests
Host Mouse
Clonality Monoclonal
Clone 1-21
Flow cytometry analysis showing intracellular staining of Daudi cells using Mouse IgG2b kappa Isotype Control APC (blue) or ab167133 at 5 µl (0.25µg) per test dilution (purple). Total viable cells were used for analysis.

Anti-Tcl1 antibody [EPR3949] - ab108978 from Abcam

Prices $99.00, $357.00
Sizes 10 µl, 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3949
Overlay histogram showing Ramos cells stained with ab108978 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab108978, 1/1000 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H&L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (0.1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in Ramos cells fixed with 4% paraformaldehyde (10 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

TCL1A Antibody - AF4847 from Novus Biologicals

Prices $99.00, $329.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal
Western blot shows lysates of Daudi human Burkitt's lymphoma cell line and Ramos human Burkitt's lymphoma cell line. PVDF membrane was probed with 1 µg/mL Goat Anti-Human TCL1A Antigen Affinity-purified Polyclonal Antibody (Catalog # AF4847) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF017). For additional reference, recombinant human TCL1A was included. A specific band for TCL1A was detected at approximately 14 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 2.

TCL1A Antibody - H00008115-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

TCL1A Antibody (1-21) - NBP1-43253 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1-21
Flow Cytometry: TCL1 Antibody (1-21) [NBP1-43253] - Staining of Daudi cells with 0.25 ug of Mouse IgG2b kappa Isotype Control Purified (open histogram) or 0.25 ug of Anti-Human TCL1 Purified (filled histogram) followed by Anti-Mouse IgG Biotin and Streptavidin PE. Total viable cells were used for analysis

TCL1A Antibody (1C4) - H00008115-M06 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1C4

TCL1A Antibody (3G10) - H00008115-M07 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3G10

TCL1A Antibody - NB100-77332 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: TCL1 Antibody [NB100-77332] - (0.1ug/ml) staining of Jurkat Cell lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

TCL1A Antibody - NBP1-54693 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: TCL1A Antibody [NBP1-54693] - Human Brain lysate, concentration 0.2-1 ug/ml.

TCL1A Antibody (2F1) - H00008115-M03 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2F1
Immunocytochemistry/Immunofluorescence: TCL1A Antibody (2F1) [H00008115-M03] - Analysis of monoclonal antibody to TCL1A on HeLa cell. Antibody concentration 10 ug/ml

TCL1A Antibody (3A4) - H00008115-M13 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3A4
ELISA: TCL1 Antibody (3A4) [H00008115-M13] - Detection limit for recombinant GST tagged TCL1A is approximately 0.1ng/ml as a capture antibody.

TCL1A Antibody (3H6) - H00008115-M09 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3H6
ELISA: TCL1 Antibody (3H6) [H00008115-M09] - Detection limit for recombinant GST tagged TCL1A is approximately 0.03ng/ml as a capture antibody.
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