Gene Symbol | KHSRP |
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Entrez Gene | 8570 |
Alt Symbol | FBP2, FUBP2, KSRP |
Species | Human |
Gene Type | protein-coding |
Description | KH-type splicing regulatory protein |
Other Description | FUSE binding protein 2|FUSE-binding protein 2|KH type-splicing regulatory protein|far upstream element-binding protein 2|p75 |
Swissprots | Q92945 Q9UNT5 O00301 Q5U4P6 Q9UQH5 Q59EZ9 |
Accessions | AAD29861 AAD29862 EAW69095 EAW69096 EAW69097 Q92945 AA976482 AB209662 BAD92899 AK300957 BAG62585 BC009473 BC085004 AAH85004 BQ186683 CB216491 CF123311 DC388502 U69126 AAC50892 U94832 AAB53222 XM_005259668 XP_005259725 XM_011528395 XP_011526697 NM_003685 NP_003676 |
Function | Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single- stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'- UTR, possibly by recruiting degradation machinery to ARE- containing mRNAs. {ECO:0000250, ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:8940189, ECO:0000269|PubMed:9136930}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:19198587}. Cytoplasm {ECO:0000269|PubMed:19198587}. Note=A small proportion is also found in the cytoplasm of neuronal cell bodies and dendrites. {ECO:0000250}. |
Tissue Specificity | Detected in neural and non-neural cell lines. |
Far upstream element-binding protein 2 (KHSRP), Human, ELISA Kit - CSB-EL012158HU from ARP American Research Products
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KH-type splicing regulatory protein, ELISA Kit - MBS924450 from MyBioSource
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Human Far upstream element-binding protein 2(KHSRP) ELISA kit - CSB-EL012158HU from Cusabio
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Human FBP2 ELISA Kit - E015608 from Biobool
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Human KHSRP ELISA Kit - E021636 from Biobool
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anti-FBP2 antibody [1E11] - ARG57009 from Arigo Biolaboratories
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KHSRP ELISA Kit (Human) (OKCA01238) - OKCA01238 from Aviva Systems Biology
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Human Far upstream element-binding protein 2 (KHSRP) ELISA Kit - AE36984HU from ARP American Research Products
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