KHSRP
| Gene Symbol | KHSRP |
|---|---|
| Entrez Gene | 8570 |
| Alt Symbol | FBP2, FUBP2, KSRP |
| Species | Human |
| Gene Type | protein-coding |
| Description | KH-type splicing regulatory protein |
| Other Description | FUSE binding protein 2|FUSE-binding protein 2|KH type-splicing regulatory protein|far upstream element-binding protein 2|p75 |
| Swissprots | Q92945 Q9UNT5 O00301 Q5U4P6 Q9UQH5 Q59EZ9 |
| Accessions | AAD29861 AAD29862 EAW69095 EAW69096 EAW69097 Q92945 AA976482 AB209662 BAD92899 AK300957 BAG62585 BC009473 BC085004 AAH85004 BQ186683 CB216491 CF123311 DC388502 U69126 AAC50892 U94832 AAB53222 XM_005259668 XP_005259725 XM_011528395 XP_011526697 NM_003685 NP_003676 |
| Function | Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single- stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'- UTR, possibly by recruiting degradation machinery to ARE- containing mRNAs. {ECO:0000250, ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:8940189, ECO:0000269|PubMed:9136930}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:19198587}. Cytoplasm {ECO:0000269|PubMed:19198587}. Note=A small proportion is also found in the cytoplasm of neuronal cell bodies and dendrites. {ECO:0000250}. |
| Tissue Specificity | Detected in neural and non-neural cell lines. |
FBP2 CRISPR/Cas9 KO Plasmid (h) - sc-404139 from Santa Cruz Biotechnology
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FBP2 HDR Plasmid (h) - sc-404139-HDR from Santa Cruz Biotechnology
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FBP2 Double Nickase Plasmid (h) - sc-404139-NIC from Santa Cruz Biotechnology
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FBP2 Double Nickase Plasmid (h2) - sc-404139-NIC-2 from Santa Cruz Biotechnology
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FBP2 CRISPR Activation Plasmid (h) - sc-404139-ACT from Santa Cruz Biotechnology
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FBP2 CRISPR Activation Plasmid (h2) - sc-404139-ACT-2 from Santa Cruz Biotechnology
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FBP2 Lentiviral Activation Particles (h) - sc-404139-LAC from Santa Cruz Biotechnology
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FBP2 Lentiviral Activation Particles (h2) - sc-404139-LAC-2 from Santa Cruz Biotechnology
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FBP2 siRNA (h) - sc-44831 from Santa Cruz Biotechnology
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FBP2 shRNA Plasmid (h) - sc-44831-SH from Santa Cruz Biotechnology
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FBP2 shRNA (h) Lentiviral Particles - sc-44831-V from Santa Cruz Biotechnology
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FBP2 RNAi - H00008789-R01 from Novus Biologicals
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KHSRP RNAi - H00008570-R01 from Novus Biologicals
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MISSION® esiRNA - EHU016701 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11051 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11051 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07511 from Sigma-Aldrich
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KHSRP siRNA (Human) - CRH5638 from Cohesion Biosciences
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shRNA set against Human KHSRP(NM_003685.2) - SHH137981 from Creative biogene
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KHSRP shRNA Plasmid (Human) - CHH5638 from Cohesion Biosciences
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KHSRP miRNA 3'UTR clone - MiUTR1H-05196 from Creative biogene
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