| Gene Symbol |
KHSRP
|
| Entrez Gene |
8570
|
| Alt Symbol |
FBP2, FUBP2, KSRP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
KH-type splicing regulatory protein
|
| Other Description |
FUSE binding protein 2|FUSE-binding protein 2|KH type-splicing regulatory protein|far upstream element-binding protein 2|p75
|
| Swissprots |
Q92945 Q9UNT5 O00301 Q5U4P6 Q9UQH5 Q59EZ9
|
| Accessions |
AAD29861 AAD29862 EAW69095 EAW69096 EAW69097 Q92945 AA976482 AB209662 BAD92899 AK300957 BAG62585 BC009473 BC085004 AAH85004 BQ186683 CB216491 CF123311 DC388502 U69126 AAC50892 U94832 AAB53222 XM_005259668 XP_005259725 XM_011528395 XP_011526697 NM_003685 NP_003676
|
| Function |
Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single- stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'- UTR, possibly by recruiting degradation machinery to ARE- containing mRNAs. {ECO:0000250, ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:8940189, ECO:0000269|PubMed:9136930}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:19198587}. Cytoplasm {ECO:0000269|PubMed:19198587}. Note=A small proportion is also found in the cytoplasm of neuronal cell bodies and dendrites. {ECO:0000250}.
|
| Tissue Specificity |
Detected in neural and non-neural cell lines.
|