Gene Symbol | KHSRP |
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Entrez Gene | 8570 |
Alt Symbol | FBP2, FUBP2, KSRP |
Species | Human |
Gene Type | protein-coding |
Description | KH-type splicing regulatory protein |
Other Description | FUSE binding protein 2|FUSE-binding protein 2|KH type-splicing regulatory protein|far upstream element-binding protein 2|p75 |
Swissprots | Q92945 Q9UNT5 O00301 Q5U4P6 Q9UQH5 Q59EZ9 |
Accessions | AAD29861 AAD29862 EAW69095 EAW69096 EAW69097 Q92945 AA976482 AB209662 BAD92899 AK300957 BAG62585 BC009473 BC085004 AAH85004 BQ186683 CB216491 CF123311 DC388502 U69126 AAC50892 U94832 AAB53222 XM_005259668 XP_005259725 XM_011528395 XP_011526697 NM_003685 NP_003676 |
Function | Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single- stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'- UTR, possibly by recruiting degradation machinery to ARE- containing mRNAs. {ECO:0000250, ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:8940189, ECO:0000269|PubMed:9136930}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:19198587}. Cytoplasm {ECO:0000269|PubMed:19198587}. Note=A small proportion is also found in the cytoplasm of neuronal cell bodies and dendrites. {ECO:0000250}. |
Tissue Specificity | Detected in neural and non-neural cell lines. |
Human KHSRP peptide - ab111652 from Abcam
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Human KHSRP protein fragment - ab152894 from Abcam
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KHSRP peptide - ab107905 from Abcam
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FBP2 Antibody Blocking Peptide - LS-E8422 from LifeSpan Bioscience
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FBP2 Antibody Blocking Peptide - LS-E17399 from LifeSpan Bioscience
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FBP2 Antibody Blocking Peptide - LS-E17336 from LifeSpan Bioscience
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KHSRP / FBP2 Antibody Blocking Peptide - LS-E14770 from LifeSpan Bioscience
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KHSRP / FBP2 Antibody Blocking Peptide - LS-E14771 from LifeSpan Bioscience
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KHSRP / FBP2 Antibody Blocking Peptide - LS-E8513 from LifeSpan Bioscience
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FBP2 Recombinant Protein - H00008789-P01 from Novus Biologicals
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Recombinant Human KHSRP Protein - H00008570-Q01 from Novus Biologicals
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Recombinant Human FBP2 Protein - H00008789-Q01 from Novus Biologicals
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Recombinant Human FBP2 Protein - NBP2-23061 from Novus Biologicals
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KHSRP-Antibody-Center-Blocking-peptide - BP11709c from Abgent, a WuXi AppTec company
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KHSRP-Antibody-N-term-Blocking-Peptide - BP6866a from Abgent, a WuXi AppTec company
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Human FBP2 protein - orb168332 from Biorbyt
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FBP2 Blocking Peptide - 33R-10138 from Fitzgerald
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FBP2 Blocking Peptide - 33R-10051 from Fitzgerald
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FBP2 protein (His tag) - 80R-2586 from Fitzgerald
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KHSRP Blocking Peptide - 33R-9939 from Fitzgerald
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KHSRP - H00008570-Q01-10 from Acris Antibodies
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KHSRP - H00008570-Q01-25 from Acris Antibodies
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Recombinant Human Far upstream element-binding protein 2(KHSRP) - CSB-YP821716HU CSB-EP821716HU CSB-BP821716HU CSB-MP821716HU from Cusabio
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KHSRP - TP317220 from Acris Antibodies
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Recombinant Human KHSRP protein, His-tagged - KHSRP-894H from Creative Biomart
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