PEG10

Gene Symbol PEG10
Entrez Gene 23089
Alt Symbol EDR, HB-1, MEF3L, Mar2, Mart2, RGAG3
Species Human
Gene Type protein-coding
Description paternally expressed 10
Other Description MEF3 like 1|embryonal carcinoma differentiation regulated|mammalian retrotransposon-derived protein 2|myelin expression factor 3-like protein 1|paternally expressed gene 10 protein|retrotransposon gag domain-containing protein 3|retrotransposon-derived gag-like polyprotein|retrotransposon-derived protein PEG10|ty3/Gypsy-like protein
Swissprots Q96A68 Q9UPV1 Q86TG7
Accessions AAS07484 EAW76781 Q86TG7 AB028974 BAA83003 AB049150 BAB68387 AB049834 BAB43951 AF038197 AF216076 AK025529 AK299837 BAG61702 AL589326 BC015448 BC050659 AAH50659 BP250746 DA297295 DA683494 R17262 R79712 NM_001040152 NP_001035242 NM_001172437 NP_001165908 NM_001172438 NP_001165909 NM_001184961 NP_001171890 NM_001184962 NP_001171891 NM_015068 NP_055883
Function Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. May also have a role in cell growth promotion and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1. Involved at the immediate early stage of adipocyte differentiation (By similarity). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter (By similarity). {ECO:0000250}.
Subcellular Location Nucleus. Cytoplasm. Note=Detected predominantly in the cytoplasm of breast and prostate carcinomas, in hepatocellular carcinoma (HCC) and B-cell chronic lymphocytic leukemia (B-CLL) cells and in the Hep-G2 cell line. Colocalized with ALK1.
Tissue Specificity Expressed in the cytotrophoblast layer but not in the overlying syncytiotrophoblast of the placenta. Expressed in prostate and breast carcinomas but not in normal breast and prostate epithelial cells. Expressed in the Hep-G2 cell line (at protein level). Expressed in brain, liver, spleen, kidney, thymus, lung, ovary, testis, reactive lymph node, skeletal muscle, adipose tissue and placenta. Expressed in pancreatic and hepatocellular carcinomas (HCC). {ECO:0000269|PubMed:11318613, ECO:0000269|PubMed:12810624, ECO:0000269|PubMed:15611116, ECO:0000269|PubMed:16423995, ECO:0000269|PubMed:17621626}.

Human-PEG10-cDNA-Clone - DC07827 from Abgent, a WuXi AppTec company

Prices $438.75
Sizes 10 µg
Species Human
Accession BC050659

PEG10 - MBS1274954 from MyBioSource

Prices $175.00
Sizes 10ug plasmid + 200ul glycerol stock
Species Human
Accession BC050659

Human PEG10 ORF Clone(NM_001040152.1) - CDCR344071 from Creative biogene

Species Human

Human PEG10 ORF Clone(NM_001184961.1) - CDCR357687 from Creative biogene

Species Human

Human PEG10 ORF Clone(NM_001184962.1) - CDCR357690 from Creative biogene

Species Human

Human PEG10 ORF clone (NM_015068.3) - CDCL147981 from Creative biogene

Species Human

Mouse PEG10 ORF clone (NM_001172437.1) - CDCL147983 from Creative biogene

Species Human

Mouse PEG10 ORF clone (NM_001172438.1) - CDCL147985 from Creative biogene

Species Human

Human PEG10 ORF Clone (BC050659) - CDCS407022 from Creative biogene

Species Human
Accession Q86TG7

Human PEG10 cDNA Clone(NM_001040152.1) - CDFH014048 from Creative biogene

Species Human

Human PEG10 cDNA Clone(NM_001172438.1) - CDFH014049 from Creative biogene

Species Human

Human PEG10 cDNA Clone(NM_001184962.1) - CDFH014050 from Creative biogene

Species Human

Human PEG10 cDNA Clone(NM_015068.3) - CDFH014052 from Creative biogene

Species Human
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