PEG10

Gene Symbol	PEG10
Entrez Gene	23089
Alt Symbol	EDR, HB-1, MEF3L, Mar2, Mart2, RGAG3
Species	Human
Gene Type	protein-coding
Description	paternally expressed 10
Other Description	MEF3 like 1|embryonal carcinoma differentiation regulated|mammalian retrotransposon-derived protein 2|myelin expression factor 3-like protein 1|paternally expressed gene 10 protein|retrotransposon gag domain-containing protein 3|retrotransposon-derived gag-like polyprotein|retrotransposon-derived protein PEG10|ty3/Gypsy-like protein
Swissprots	Q96A68 Q9UPV1 Q86TG7
Accessions	AAS07484 EAW76781 Q86TG7 AB028974 BAA83003 AB049150 BAB68387 AB049834 BAB43951 AF038197 AF216076 AK025529 AK299837 BAG61702 AL589326 BC015448 BC050659 AAH50659 BP250746 DA297295 DA683494 R17262 R79712 NM_001040152 NP_001035242 NM_001172437 NP_001165908 NM_001172438 NP_001165909 NM_001184961 NP_001171890 NM_001184962 NP_001171891 NM_015068 NP_055883
Function	Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. May also have a role in cell growth promotion and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1. Involved at the immediate early stage of adipocyte differentiation (By similarity). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus. Cytoplasm. Note=Detected predominantly in the cytoplasm of breast and prostate carcinomas, in hepatocellular carcinoma (HCC) and B-cell chronic lymphocytic leukemia (B-CLL) cells and in the Hep-G2 cell line. Colocalized with ALK1.
Tissue Specificity	Expressed in the cytotrophoblast layer but not in the overlying syncytiotrophoblast of the placenta. Expressed in prostate and breast carcinomas but not in normal breast and prostate epithelial cells. Expressed in the Hep-G2 cell line (at protein level). Expressed in brain, liver, spleen, kidney, thymus, lung, ovary, testis, reactive lymph node, skeletal muscle, adipose tissue and placenta. Expressed in pancreatic and hepatocellular carcinomas (HCC). {ECO:0000269|PubMed:11318613, ECO:0000269|PubMed:12810624, ECO:0000269|PubMed:15611116, ECO:0000269|PubMed:16423995, ECO:0000269|PubMed:17621626}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PEG10 full length protein - ab161530 from Abcam Category Protein Source Wheat germ Species Human

EDR / PEG10 Antibody Blocking Peptide - LS-E1848 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EDR / PEG10 Antibody Blocking Peptide - LS-E18473 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EDR / PEG10 Antibody Blocking Peptide - LS-E18474 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PEG10 Protein - H00023089-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

PEG10-Antibody-N-term-Blocking-peptide - BP12661a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PEG10 - H00023089-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

PEG10 fusion protein - Ag5754 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

PEG10 fusion protein - ag5839 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human PEG10, GST-tagged - PEG10-1640H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Retrotransposon-derived protein PEG10(PEG10) - CSB-YP768203HU CSB-EP768203HU CSB-BP768203HU CSB-MP768203HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

PEG10 (transcript variant 1) - TP308683 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

PEG10 Recombinant Protein Antigen - NBP2-13749PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

PEG10 Recombinant Protein Antigen - NBP2-48592PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

HB-1 (18-41) - C08107 from Creative Peptides Category Peptide

HB-1 (26-41) - C08108 from Creative Peptides Category Peptide

PEG10 Peptide, Human - M34GP11581H from Creative Peptides Category Peptide Source Synthetic. Species Human

PEG10 peptide - orb73121 from Biorbyt Category Peptide Prices $238.00 Sizes 500 µg

Retrotransposon-derived protein PEG10 (PEG10), Recombinant Protein - MBS1395695 from MyBioSource Category Protein Prices $1,515.00, $1,515.00, $1,745.00, $1,745.00, $2,595.00, $2,595.00, $3,040.00, $3,040.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Recombinant Human PEG10 protein, GST-tagged - PEG10-21H from Creative Biomart Category Protein Source Wheat Germ Species Human

Recombinant Human PEG10 protein, Myc/DDK-tagged - PEG10-22H from Creative Biomart Category Protein Source HEK293 Species Human

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