PEG10

Gene Symbol PEG10
Entrez Gene 23089
Alt Symbol EDR, HB-1, MEF3L, Mar2, Mart2, RGAG3
Species Human
Gene Type protein-coding
Description paternally expressed 10
Other Description MEF3 like 1|embryonal carcinoma differentiation regulated|mammalian retrotransposon-derived protein 2|myelin expression factor 3-like protein 1|paternally expressed gene 10 protein|retrotransposon gag domain-containing protein 3|retrotransposon-derived gag-like polyprotein|retrotransposon-derived protein PEG10|ty3/Gypsy-like protein
Swissprots Q96A68 Q9UPV1 Q86TG7
Accessions AAS07484 EAW76781 Q86TG7 AB028974 BAA83003 AB049150 BAB68387 AB049834 BAB43951 AF038197 AF216076 AK025529 AK299837 BAG61702 AL589326 BC015448 BC050659 AAH50659 BP250746 DA297295 DA683494 R17262 R79712 NM_001040152 NP_001035242 NM_001172437 NP_001165908 NM_001172438 NP_001165909 NM_001184961 NP_001171890 NM_001184962 NP_001171891 NM_015068 NP_055883
Function Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. May also have a role in cell growth promotion and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1. Involved at the immediate early stage of adipocyte differentiation (By similarity). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter (By similarity). {ECO:0000250}.
Subcellular Location Nucleus. Cytoplasm. Note=Detected predominantly in the cytoplasm of breast and prostate carcinomas, in hepatocellular carcinoma (HCC) and B-cell chronic lymphocytic leukemia (B-CLL) cells and in the Hep-G2 cell line. Colocalized with ALK1.
Tissue Specificity Expressed in the cytotrophoblast layer but not in the overlying syncytiotrophoblast of the placenta. Expressed in prostate and breast carcinomas but not in normal breast and prostate epithelial cells. Expressed in the Hep-G2 cell line (at protein level). Expressed in brain, liver, spleen, kidney, thymus, lung, ovary, testis, reactive lymph node, skeletal muscle, adipose tissue and placenta. Expressed in pancreatic and hepatocellular carcinomas (HCC). {ECO:0000269|PubMed:11318613, ECO:0000269|PubMed:12810624, ECO:0000269|PubMed:15611116, ECO:0000269|PubMed:16423995, ECO:0000269|PubMed:17621626}.

Peg10 CRISPR/Cas9 KO Plasmid (h) - sc-406028 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Peg10 HDR Plasmid (h) - sc-406028-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Peg10 Double Nickase Plasmid (h) - sc-406028-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Peg10 Double Nickase Plasmid (h2) - sc-406028-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Peg10 CRISPR Activation Plasmid (h) - sc-406028-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Peg10 CRISPR Activation Plasmid (h2) - sc-406028-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Peg10 Lentiviral Activation Particles (h) - sc-406028-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Peg10 Lentiviral Activation Particles (h2) - sc-406028-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Peg10 siRNA (h) - sc-89888 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Peg10 shRNA Plasmid (h) - sc-89888-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Peg10 shRNA (h) Lentiviral Particles - sc-89888-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN16611 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16611 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

PEG10 siRNA (Human) - CRH7988 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human PEG10 (NM_001040152.1) - SHH373404 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human PEG10(NM_015068.3) - SHR103908 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human PEG10(NM_001040152.1) - SHR103944 from Creative biogene

Category siRNA
Species Reactivities Human

PEG10 shRNA Plasmid (Human) - CHH7988 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PEG10 miRNA 3'UTR clone - MiUTR1H-07775 from Creative biogene

Species Reactivities Human

PEG10 miRNA 3'UTR clone - MiUTR1H-07776 from Creative biogene

Species Reactivities Human
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