DLL4

Gene Symbol	DLL4
Entrez Gene	54567
Alt Symbol	hdelta2
Species	Human
Gene Type	protein-coding
Description	delta-like 4 (Drosophila)
Other Description	delta 4|delta ligand 4|delta-like 4 homolog|delta-like 4 protein|delta-like protein 4|delta4|drosophila Delta homolog 4|notch ligand DLL4|notch ligand delta-2
Swissprots	Q9NR61 Q3KP23 Q9NQT9
Accessions	EAW92466 Q9NR61 AB036931 BAB16085 AB043894 BAB18581 AF253468 AAF76427 AF279305 AAF81912 AI478830 AK308755 AK313831 BAG36565 AY358894 AAQ89253 BC106950 AAI06951 BI820351 DA089757 NM_019074 NP_061947
Function	Involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation is required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types. During spinal cord neurogenesis, inhibits V2a interneuron fate. {ECO:0000269|PubMed:17728344, ECO:0000269|PubMed:20616313}.
Subcellular Location	Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Tissue Specificity	Expressed in vascular endothelium.
Top Pathways	Notch signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human DLL4 (NP_061947) VersaClone cDNA - RDC1102 from R&D Systems Prices $499.00 Sizes 10 µg Species Human

DLL4 - MBS1276923 from MyBioSource Species Human Accession BC106950

Human DLL4 ORF Clone(NM_019074.3) - CDCL161180 from Creative Biomart Species Human Accession NM_019074.3

Human DLL4/Delta-like 4 Gene ORF cDNA clone in cloning vector - HG10171-M from Sino Biological Species Human

Human DLL4/Delta-like 4 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10171-CF from Sino Biological Species Human

Human DLL4/Delta-like 4 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10171-NM from Sino Biological Species Human

Human DLL4/Delta-like 4 Gene ORF cDNA clone expression plasmid, N-HA tag - HG10171-NY from Sino Biological Species Human

Human DLL4/Delta-like 4 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10171-ACG from Sino Biological Species Human

Human DLL4/Delta-like 4 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10171-CM from Sino Biological Species Human

Human DLL4/Delta-like 4 Gene ORF cDNA clone expression plasmid - HG10171-M-N from Sino Biological Species Human

Human DLL4/Delta-like 4 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10171-ACR from Sino Biological Species Human

Human DLL4/Delta-like 4 Gene ORF cDNA clone expression plasmid, N-His tag - HG10171-NH from Sino Biological Species Human

Human DLL4/Delta-like 4 Gene ORF cDNA clone expression plasmid - HG10171-UT from Sino Biological Species Human

Human DLL4/Delta-like 4 Gene ORF cDNA clone expression plasmid, C-HA tag - HG10171-CY from Sino Biological Species Human

Human DLL4/Delta-like 4 Gene ORF cDNA clone expression plasmid, C-His tag - HG10171-CH from Sino Biological Species Human

Human DLL4/Delta-like 4 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10171-NF from Sino Biological Species Human

Mouse DLL4 (NP_062327) VersaClone cDNA - RDC1332 from R&D Systems Prices $499.00 Sizes 10 µg Species Mouse

Human DLL4 ORF Clone (BC106950) - CDCS414946 from Creative biogene Species Human Accession Q9NR61

Human DLL4 ORF clone (NM_019074.2) - CDCB157571 from Creative biogene Species Human

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