DLL4

Gene Symbol DLL4
Entrez Gene 54567
Alt Symbol hdelta2
Species Human
Gene Type protein-coding
Description delta-like 4 (Drosophila)
Other Description delta 4|delta ligand 4|delta-like 4 homolog|delta-like 4 protein|delta-like protein 4|delta4|drosophila Delta homolog 4|notch ligand DLL4|notch ligand delta-2
Swissprots Q9NR61 Q3KP23 Q9NQT9
Accessions EAW92466 Q9NR61 AB036931 BAB16085 AB043894 BAB18581 AF253468 AAF76427 AF279305 AAF81912 AI478830 AK308755 AK313831 BAG36565 AY358894 AAQ89253 BC106950 AAI06951 BI820351 DA089757 NM_019074 NP_061947
Function Involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation is required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types. During spinal cord neurogenesis, inhibits V2a interneuron fate. {ECO:0000269|PubMed:17728344, ECO:0000269|PubMed:20616313}.
Subcellular Location Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Tissue Specificity Expressed in vascular endothelium.
Top Pathways Notch signaling pathway

Delta-4 CRISPR/Cas9 KO Plasmid (h) - sc-401271 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Delta-4 HDR Plasmid (h) - sc-401271-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Delta-4 Double Nickase Plasmid (h) - sc-401271-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Delta-4 Double Nickase Plasmid (h2) - sc-401271-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Delta-4 CRISPR Activation Plasmid (h) - sc-401271-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Delta-4 CRISPR Activation Plasmid (h2) - sc-401271-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Delta-4 Lentiviral Activation Particles (h) - sc-401271-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Delta-4 Lentiviral Activation Particles (h2) - sc-401271-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Delta-4 siRNA (h) - sc-39667 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Delta-4 shRNA Plasmid (h) - sc-39667-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Delta-4 shRNA (h) Lentiviral Particles - sc-39667-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

DLL4 RNAi - H00054567-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU017581 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN7298 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7298 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR12424 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr12424

DLL4 siRNA (Human) - CRJ0139 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

DLL4 - MBS8200406 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

DLL4 shRNA Plasmid (Human) - CHJ0139 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

DLL4 miRNA 3'UTR clone - MiUTR3H-07444 from Creative biogene

Species Reactivities Human
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