DLL4

Gene Symbol DLL4
Entrez Gene 54567
Alt Symbol hdelta2
Species Human
Gene Type protein-coding
Description delta-like 4 (Drosophila)
Other Description delta 4|delta ligand 4|delta-like 4 homolog|delta-like 4 protein|delta-like protein 4|delta4|drosophila Delta homolog 4|notch ligand DLL4|notch ligand delta-2
Swissprots Q9NR61 Q3KP23 Q9NQT9
Accessions EAW92466 Q9NR61 AB036931 BAB16085 AB043894 BAB18581 AF253468 AAF76427 AF279305 AAF81912 AI478830 AK308755 AK313831 BAG36565 AY358894 AAQ89253 BC106950 AAI06951 BI820351 DA089757 NM_019074 NP_061947
Function Involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation is required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types. During spinal cord neurogenesis, inhibits V2a interneuron fate. {ECO:0000269|PubMed:17728344, ECO:0000269|PubMed:20616313}.
Subcellular Location Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Tissue Specificity Expressed in vascular endothelium.
Top Pathways Notch signaling pathway

DLL4 Antibody - 2589 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HUVEC and COS cells, untransfected or transiently transfected with a construct expressing human DLL4, using DLL4 Antibody.

Delta-4 (G-12) - sc-365429 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Delta-4 (G-12): sc-365429. Western blot analysis of Delta-4 expression in K-562 whole cell lysate.

Delta-4 (C-20) - sc-18640 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Delta-4 (C-20): sc-18640. Immunoperoxidase staining of formalin fixed, paraffin-embedded human duodenum tissue showing cytoplasmic staining of glandular cells.

Delta-4 (H-70) - sc-28915 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Delta-4 (H-70): sc-28915. Immunofluorescence staining of methanol-fixed HeLa cells showing membrane localization.

Delta-4 (T-20) - sc-18639 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-DLL4 antibody - ab7280 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-DLL4 antibody - ab61031 from Abcam

Host Mouse
Clonality Monoclonal
ab61031 staining DLL4 (red) in Human HUVEC endothelium cells by ICC/IF (Immunocytochemistry/immunofluorescence). Cells were fixed with formaldehyde, permeabilized with 0.1% Triton X-100 in PBS and blocked with 1% BSA for 30 minutes at 21°C. Samples were incubated with the primary antibody for 2 hours at 21°C. An undiluted Alexa Fluor®680-conjugated Goat anti-mouse IgG polyclonal was used as the secondary antibody. Blue - nuclei.See Abreview

Anti-DLL4 antibody - ab183532 from Abcam

Prices $376.00
Sizes 100 µl
Host Goat
Clonality Polyclonal
All lanes : Anti-DLL4 antibody (ab183532) at 0.3 µg/mlLane 1 : Human lung lysateLane 2 : Mouse lung lysateLane 3 : Rat lung lysateLysates/proteins at 35 µg per lane.developed using the ECL technique

Anti-DLL4 antibody - ab176876 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-DLL4 antibody (ab176876) at 1/500 dilutionLane 1 : Human fetal kidney lysateLane 2 : Human fetal lung lysate

Anti-DLL4 antibody - ab82334 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-DLL4 antibody (ab82334) at 1 µg/mlLane 1 : Liver (Human) Tissue Lysate - adult normal tissue (ab29889)Lane 2 : Kidney (Human) Tissue Lysate - adult normal tissue (ab30203)Lane 3 : Lung (Human) Tissue LysateLysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-DLL4 antibody - ab107518 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DLL4 antibody [4A11] - ab129365 from Abcam

Host Mouse
Clonality Monoclonal
Clone 4A11
ab129365 at 1/200 dilution (green) or negative control (red) staining DLL4 in HeLa cells by flow cytometry.

Anti-DLL4 antibody [EPR3540(N)] - ab185232 from Abcam

Host Rabbit
Clonality Monoclonal
Clone EPR3540(N)
All lanes : Anti-DLL4 antibody [EPR3540(N)] (ab185232) at 1/1000 dilutionLane 1 : Human fetal kidney lysateLane 2 : Hela cell lysateLane 3 : HepG2 cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-DLL4 antibody [MM0519-28V45] - ab135156 from Abcam

Prices $370.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone MM0519-28V45

Anti-DLL4 Antibody (Leu617) - LS-C64648 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DLL4 Antibody (Internal) - LS-C42584 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-DLL4 Antibody (aa27-525) - LS-C125453 from LifeSpan Bioscience

Prices $575.00
Sizes 500 µg
Host Rat
Clonality Monoclonal

Anti-DLL4 Antibody (aa27-525, Biotin) - LS-C125452 from LifeSpan Bioscience

Prices $650.00
Sizes 250 µg
Host Rat
Clonality Monoclonal

Anti-DLL4 Antibody - LS-C127564 from LifeSpan Bioscience

Prices $575.00
Sizes 500 µg
Host Rat
Clonality Monoclonal

Anti-DLL4 Antibody (Internal) - LS-C121719 from LifeSpan Bioscience

Prices $485.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-DLL4 Antibody (aa81-97) - LS-C149032 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-DLL4 Antibody (clone 12G28) - LS-C182616 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Hamster
Clonality Monoclonal
Clone 12G28

Anti-DLL4 Antibody (clone HMD4-2) - LS-C188667 from LifeSpan Bioscience

Prices $235.00
Sizes 100 µg
Host Hamster
Clonality Monoclonal
Clone HMD4-2

Anti-DLL4 Antibody (aa71-120) - LS-C107688 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
DLL4 antibody LS-C107688 Western blot of 721_B cell lysate.

Anti-DLL4 Antibody (Internal) - LS-C209936 from LifeSpan Bioscience

Prices $295.00
Sizes 250 µl
Host Rabbit
Clonality Polyclonal
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