DLL4

Gene Symbol	DLL4
Entrez Gene	54567
Alt Symbol	hdelta2
Species	Human
Gene Type	protein-coding
Description	delta-like 4 (Drosophila)
Other Description	delta 4|delta ligand 4|delta-like 4 homolog|delta-like 4 protein|delta-like protein 4|delta4|drosophila Delta homolog 4|notch ligand DLL4|notch ligand delta-2
Swissprots	Q9NR61 Q3KP23 Q9NQT9
Accessions	EAW92466 Q9NR61 AB036931 BAB16085 AB043894 BAB18581 AF253468 AAF76427 AF279305 AAF81912 AI478830 AK308755 AK313831 BAG36565 AY358894 AAQ89253 BC106950 AAI06951 BI820351 DA089757 NM_019074 NP_061947
Function	Involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation is required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types. During spinal cord neurogenesis, inhibits V2a interneuron fate. {ECO:0000269|PubMed:17728344, ECO:0000269|PubMed:20616313}.
Subcellular Location	Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Tissue Specificity	Expressed in vascular endothelium.
Top Pathways	Notch signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human DLL4 protein fragment - ab108557 from Abcam Category Protein Prices $352.00 Sizes 10 µg Source HEK 293 cells Species Human

Active human DLL4 protein fragment - ab84081 from Abcam Category Protein Prices $302.00 Sizes 5 µg Source HEK 293 cells Species Human

Human DLL4 peptide - ab90637 from Abcam Category Peptide

Human DLL4 protein fragment - ab153379 from Abcam Category Protein Source Wheat germ Species Human

DLL4 Antibody Blocking Peptide - LS-E17841 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DLL4 Blocking Peptide - LS-E10420 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DLL4 Partial Recombinant Protein - H00054567-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

DLL4-Antibody-C-term-Blocking-Peptide - BP9964a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human DLL4 - 1506-D4-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Ser27-Pro524, with a C-terminal 10-His tag

Recombinant Human DLL4, CF - 1506-D4-050/CF from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Ser27-Pro524, with a C-terminal 10-His tag

Human Delta 4 protein - orb83551 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Species Human

Human Delta 4 protein - orb82971 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Species Human

DLL4 Blocking Peptide - 33R-7573 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

DLL4 Blocking Peptide - 33R-7121 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

sDLL4 protein - 30R-AD008 from Fitzgerald Category Protein Prices $225.00 Sizes 25 µg Source 293 cells

Delta-like protein 4 / DLL4 - AR31113PU-N from Acris Antibodies Category Protein Prices $235.00 Sizes 25 µg Source HEK293 cells Species Human

Delta-like protein 4 / DLL4 - AR31113PU-S from Acris Antibodies Category Protein Prices $135.00 Sizes 5 µg Source HEK293 cells Species Human

Delta-like protein 4 / DLL4 - H00054567-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Delta-like protein 4 / DLL4 - H00054567-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Delta-like protein 4 / DLL4 - P5970 from Acris Antibodies Category Protein Prices $580.00 Sizes 25 µg Species Human

Delta 4 Recombinant Protein - 96-241 from ProSci Category Protein Prices $375.00 Sizes 100 µg Source HEK293 cells Species Human

Delta4 Recombinant Protein - 96-242 from ProSci Category Protein Prices $375.00 Sizes 100 µg Source HEK293 cells Species Human

sDLL-4 Recombinant Protein - 40-235 from ProSci Category Protein Prices $150.00, $250.00 Sizes 5 µg, 25 µg Source HEK293 cells Species Human

DLL4 fusion protein - ag17483 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

DLL4 fusion protein - ag16140 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

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