DHX58

Gene Symbol DHX58
Entrez Gene 79132
Alt Symbol D11LGP2, D11lgp2e, LGP2, RLR-3
Species Human
Gene Type protein-coding
Description DEXH (Asp-Glu-X-His) box polypeptide 58
Other Description RIG-I-like receptor 3|RIG-I-like receptor LGP2|RLR|RNA helicase LGP2|ortholog of mouse D11lgp2|probable ATP-dependent RNA helicase DHX58|probable ATP-dependent helicase LGP2|protein D11Lgp2 homolog
Swissprots Q96C10 Q9HAM6
Accessions EAW60796 EAW60797 EAW60798 EAW60799 EAW60800 Q96C10 AK021416 BAB13818 AK097669 BAG53507 AK225549 AK296840 BAH12441 AK300900 BAG62538 BC014949 AAH14949 BM723672 JF432115 ADZ15332 XM_011525224 XP_011523526 XR_934548 NM_024119 NP_077024
Function Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1- dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I signaling may involve the following mechanisms: competition with DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immu
Subcellular Location Cytoplasm {ECO:0000269|PubMed:19380577}.
Top Pathways RIG-I-like receptor signaling pathway

Probable ATP-dependent RNA helicase DHX58 (DHX58), Human, ELISA Kit - E01P0789 from ARP American Research Products

Category ELISA Kit
Prices $535.00, $735.00
Sizes 48 t, 96 t
Sensitivity 0.1ng/ml
Range 1.0-25ng/ml

Retinoic Acid Inducible Gene/RIG-Like Receptor, RLR, Human, ELISA Kit - E-EL-H1931 from ARP American Research Products

Category ELISA Kit
Prices $522.00
Sizes 96 t

Retinoic Acid Inducible Gene/RIG-Like Receptor, RLR, Rabbit, ELISA Kit - E-EL-RB1228 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t

Retinoic Acid Inducible Gene/RIG-Like Receptor, RLR, Chicken, ELISA Kit - E-EL-Ch0763 from ARP American Research Products

Category ELISA Kit
Prices $504.00
Sizes 96 t

Retinoic Acid Inducible Gene/RIG-Like Receptor, RLR, Porcine, ELISA Kit - E-EL-P1791 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t

Retinoic Acid Inducible Gene/RIG-Like Receptor, RLR, Monkey, ELISA Kit - E-EL-MK2041 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t

DHX58 (Human) IP-WB Antibody Pair - H00079132-PW1 from Acris Antibodies

Category Antibody Pair
Prices $610.00
Sizes 1 set

Probable ATP dependent RNA helicase DHX58 (DHX58), ELISA Kit - MBS7213202 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human RLR(Retinoic Acid Inducible Gene/RIG-Like Receptor) ELISA Kit - E-EL-H1931 from Elabscience

Category ELISA Kit
Sensitivity 0.10 ng/mL
Range 0.16—10 ng/mL

DEXH (Asp-Glu-X-His) box polypeptide 58 - MBS2602930 from MyBioSource

Category ELISA Kit
Prices $275.00, $420.00
Sizes 48 strip wells, 96 strip wells
Sensitivity the minimum detectable human RLR up to 0.06 ng/ml.
Range 20 ng/ml-0.312 ng/ml

Probable ATP-dependent RNA helicase DHX58 (DHX58), ELISA Kit - MBS7222535 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Probable ATP-dependent RNA helicase DHX58 (DHX58), ELISA Kit - MBS7227661 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Probable ATP-dependent RNA helicase DHX58 (DHX58), ELISA Kit - MBS7231064 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Probable ATP-dependent RNA helicase DHX58 (DHX58), ELISA Kit - MBS7207014 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Probable ATP-dependent RNA helicase DHX58 (DHX58), ELISA Kit - MBS7231591 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Probable ATP-dependent RNA helicase DHX58 (DHX58), ELISA Kit - MBS7237760 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Probable ATP-dependent RNA helicase DHX58 (DHX58), ELISA Kit - MBS7240151 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Probable ATP-dependent RNA helicase DHX58 (DHX58), ELISA Kit - MBS7243256 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Probable ATP-dependent RNA helicase DHX58 (DHX58), ELISA Kit - MBS7202042 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

RLR, ELISA Kit - MBS2512022 from MyBioSource

Category ELISA Kit
Prices $410.00, $490.00, $2,040.00, $3,590.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.094ng/mL
Range 0.156-10ng/mL

Human Grb7(Growth Factor Receptor Bound Protein 7) ELISA Kit - E-EL-H1931 from Iwai North America Inc.

Category ELISA Kit
Prices $580.00
Sizes 1 kit
Sensitivity 0.1 ng/mLng/mL
Range 0.16~10 ng/mL

Human DHX58 ELISA Kit - E030707 from Biobool

Category ELISA Kit

Human RLR ELISA Kit - E033350 from Biobool

Category ELISA Kit
Sensitivity 0.06 ng/ml.

anti-LGP2 antibody - ARG64555 from Arigo Biolaboratories

Category ELISA Kit
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