DHX58
| Gene Symbol | DHX58 |
|---|---|
| Entrez Gene | 79132 |
| Alt Symbol | D11LGP2, D11lgp2e, LGP2, RLR-3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | DEXH (Asp-Glu-X-His) box polypeptide 58 |
| Other Description | RIG-I-like receptor 3|RIG-I-like receptor LGP2|RLR|RNA helicase LGP2|ortholog of mouse D11lgp2|probable ATP-dependent RNA helicase DHX58|probable ATP-dependent helicase LGP2|protein D11Lgp2 homolog |
| Swissprots | Q96C10 Q9HAM6 |
| Accessions | EAW60796 EAW60797 EAW60798 EAW60799 EAW60800 Q96C10 AK021416 BAB13818 AK097669 BAG53507 AK225549 AK296840 BAH12441 AK300900 BAG62538 BC014949 AAH14949 BM723672 JF432115 ADZ15332 XM_011525224 XP_011523526 XR_934548 NM_024119 NP_077024 |
| Function | Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1- dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I signaling may involve the following mechanisms: competition with DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immu |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:19380577}. |
| Top Pathways | RIG-I-like receptor signaling pathway |
LGP2 CRISPR/Cas9 KO Plasmid (h) - sc-406991 from Santa Cruz Biotechnology
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LGP2 HDR Plasmid (h) - sc-406991-HDR from Santa Cruz Biotechnology
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LGP2 Double Nickase Plasmid (h) - sc-406991-NIC from Santa Cruz Biotechnology
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LGP2 Double Nickase Plasmid (h2) - sc-406991-NIC-2 from Santa Cruz Biotechnology
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LGP2 CRISPR Activation Plasmid (h) - sc-406991-ACT from Santa Cruz Biotechnology
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LGP2 CRISPR Activation Plasmid (h2) - sc-406991-ACT-2 from Santa Cruz Biotechnology
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LGP2 Lentiviral Activation Particles (h) - sc-406991-LAC from Santa Cruz Biotechnology
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LGP2 Lentiviral Activation Particles (h2) - sc-406991-LAC-2 from Santa Cruz Biotechnology
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LGP2 siRNA (h) - sc-93967 from Santa Cruz Biotechnology
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LGP2 shRNA Plasmid (h) - sc-93967-SH from Santa Cruz Biotechnology
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LGP2 shRNA (h) Lentiviral Particles - sc-93967-V from Santa Cruz Biotechnology
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DHX58 RNAi - H00079132-R02 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN7226 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7226 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02768 from Sigma-Aldrich
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DHX58 siRNA (Human) - CRJ2317 from Cohesion Biosciences
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DHX58 - MBS8210386 from MyBioSource
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shRNA set against Human DHX58 (NM_024119.2) - SHH277969 from Creative biogene
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DHX58 shRNA Plasmid (Human) - CHJ2317 from Cohesion Biosciences
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DHX58 miRNA 3'UTR clone - MiUTR1H-05647 from Creative biogene
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