| Gene Symbol |
DHX58
|
| Entrez Gene |
79132
|
| Alt Symbol |
D11LGP2, D11lgp2e, LGP2, RLR-3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
DEXH (Asp-Glu-X-His) box polypeptide 58
|
| Other Description |
RIG-I-like receptor 3|RIG-I-like receptor LGP2|RLR|RNA helicase LGP2|ortholog of mouse D11lgp2|probable ATP-dependent RNA helicase DHX58|probable ATP-dependent helicase LGP2|protein D11Lgp2 homolog
|
| Swissprots |
Q96C10 Q9HAM6
|
| Accessions |
EAW60796 EAW60797 EAW60798 EAW60799 EAW60800 Q96C10 AK021416 BAB13818 AK097669 BAG53507 AK225549 AK296840 BAH12441 AK300900 BAG62538 BC014949 AAH14949 BM723672 JF432115 ADZ15332 XM_011525224 XP_011523526 XR_934548 NM_024119 NP_077024
|
| Function |
Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1- dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I signaling may involve the following mechanisms: competition with DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immu
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:19380577}.
|
| Top Pathways |
RIG-I-like receptor signaling pathway
|