DHX58

Gene Symbol	DHX58
Entrez Gene	79132
Alt Symbol	D11LGP2, D11lgp2e, LGP2, RLR-3
Species	Human
Gene Type	protein-coding
Description	DEXH (Asp-Glu-X-His) box polypeptide 58
Other Description	RIG-I-like receptor 3|RIG-I-like receptor LGP2|RLR|RNA helicase LGP2|ortholog of mouse D11lgp2|probable ATP-dependent RNA helicase DHX58|probable ATP-dependent helicase LGP2|protein D11Lgp2 homolog
Swissprots	Q96C10 Q9HAM6
Accessions	EAW60796 EAW60797 EAW60798 EAW60799 EAW60800 Q96C10 AK021416 BAB13818 AK097669 BAG53507 AK225549 AK296840 BAH12441 AK300900 BAG62538 BC014949 AAH14949 BM723672 JF432115 ADZ15332 XM_011525224 XP_011523526 XR_934548 NM_024119 NP_077024
Function	Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1- dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I signaling may involve the following mechanisms: competition with DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immu
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:19380577}.
Top Pathways	RIG-I-like receptor signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human DHX58 full length protein - ab153504 from Abcam Category Protein Source Wheat germ Species Human

DHX58 / LGP2 Antibody Blocking Peptide - LS-E13078 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DHX58 / LGP2 Antibody Blocking Peptide - LS-E30398 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

DHX58 / LGP2 Antibody Blocking Peptide - LS-E30399 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

DHX58 / LGP2 Antibody Blocking Peptide - LS-E30400 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

DHX58 / LGP2 Antibody Blocking Peptide - LS-E26437 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human DHX58 Protein - H00079132-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

DHX58 Blocking Peptide - NBP1-76389PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

DHX58 Blocking Peptide - NBP1-76390PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

DHX58 Peptide - NBP1-76391PEP from Novus Biologicals Category Peptide Prices $149.00 Sizes 50 µg Species Human

LGP2 blocking peptide - GTX88752-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

DHX58 Blocking Peptide - 33R-1634 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

DHX58 Peptide - AC21-1276-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

DHX58 - H00079132-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

DHX58 - H00079132-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

DHX58 Control Peptide - AP30503CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

DHX58 Control Peptide - AP30504CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

DHX58 Control Peptide - AP30505CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

LGP2 Peptide - 4353P from ProSci Category Peptide Species Human

LGP2 Peptide - 4355P from ProSci Category Peptide Species Human

LGP2 Peptide - 46-863P from ProSci Category Peptide Species Human

LGP2 Peptide - 4351P from ProSci Category Peptide Species Human

DHX58 fusion protein - ag1910 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human Probable ATP-dependent RNA helicase DHX58(DHX58) - CSB-YP822187HU CSB-EP822187HU CSB-BP822187HU CSB-MP822187HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

DHX58 Protein - abx163167 from Abbexa Category Protein Species Human

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