PA2G4

Gene Symbol	PA2G4
Entrez Gene	5036
Alt Symbol	EBP1, HG4-1, p38-2G4
Species	Human
Gene Type	protein-coding
Description	proliferation-associated 2G4, 38kDa
Other Description	ErbB-3 binding protein 1|ErbB3-binding protein Ebp1|cell cycle protein p38-2G4 homolog|erbB3-binding protein 1|proliferation-associated 2G4, 38kD|proliferation-associated protein 2G4
Swissprots	Q9UM59 O43846 Q9UQ80
Accessions	AAD05561 EAW96884 EAW96885 Q9UQ80 AK291796 BAF84485 BC001951 AAH01951 BC007561 AAH07561 BC019222 AAH19222 BC032111 AAH32111 BC069786 AAH69786 BC072007 AAH72007 BU683753 DQ893446 ABM84372 DQ896751 ABM87750 U50137 AAA91484 U59435 AAB91536 U87954 AAD00646 NM_006191 NP_006182
Function	May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity). {ECO:0000250|UniProtKB:P50580, ECO:0000250|UniProtKB:Q6AYD3, ECO:0000269|PubMed:11268000, ECO:0000269|PubMed:12682367, ECO:0000269|PubMed:15064750, ECO:000026
Subcellular Location	Isoform 1: Cytoplasm {ECO:0000269|PubMed:16832058, ECO:0000269|PubMed:19037095}. Nucleus, nucleolus {ECO:0000269|PubMed:16832058, ECO:0000269|PubMed:19037095}. Note=Tranlocates to the nucleus upon treatment with HRG. Phosphorylation at Ser-361 by PKC/PRKCD regulates its nucleolar localization. {ECO:0000269|PubMed:16832058}.
Tissue Specificity	Isoform 2 is undetectable whereas isoform 1 is strongly expressed in cancer cells (at protein level). Isoform 1 and isoform 2 are widely expressed, including heart, brain, lung, pancreas, skeletal muscle, kidney, placenta and liver. {ECO:0000269|PubMed:10682683, ECO:0000269|PubMed:15064750, ECO:0000269|PubMed:19037095}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PA2G4 / EBP1 ELISA Kit (Sandwich ELISA) - LS-F6846 from LifeSpan Bioscience Category ELISA Kit Prices $790.00 Sizes 1 plate Sensitivity 0.312 ng/ml Range 0.312-20 ng/ml

Human PA2G4 ELISA Kit - abx152617 from Abbexa Category ELISA Kit Sensitivity 0.113 ng/ml Range 0.313 ng/ml - 20 ng/ml

Proliferation Associated Protein 2G4, PA2G4, Human, ELISA Kit - E-EL-H0868 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.188 Range 0.313-20ng/mL

Proliferation Associated Protein 2G4 (PA2G4), Human, ELISA Kit - SEL980Hu from ARP American Research Products Category ELISA Kit Prices $790.00 Sizes 96 t Sensitivity 0.113ng/mL Range 0.312-20ng/mL

Proliferation-associated protein 2G4, PA2G4, Human, ELISA Kit - E1733h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/mL

Proliferation Associated Protein 2G4, PA2G4, Rabbit, ELISA Kit - E-EL-RB1472 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Proliferation Associated Protein 2G4, PA2G4, Chicken, ELISA Kit - E-EL-Ch1906 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Proliferation Associated Protein 2G4, PA2G4, Porcine, ELISA Kit - E-EL-P1317 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Proliferation Associated Protein 2G4, PA2G4, Monkey, ELISA Kit - E-EL-MK1356 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

PA2G4 (Human) IP-WB Antibody Pair - H00005036-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

PA2G4 (Human) Matched Antibody Pair - H00005036-AP21 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Human PA2G4(Proliferation Associated Protein 2G4) ELISA Kit - E-EL-H0868 from Elabscience Category ELISA Kit Sensitivity 0.19 ng/mL Range 0.31—20 ng/mL

Human PA2G4 (Proliferation Associated Protein 2G4) CLIA Kit - E-CL-H0601 from Elabscience Category CLIA Kit Sensitivity 37.50 pg/mL Range Average Recovery (%)

PA2G4, ELISA Kit - MBS2508314 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/mL Range 0.313--20ng/mL

PA2G4, ELISA Kit - MBS2503222 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/mL Range 0.313-20ng/mL

PA2G4, ELISA Kit - MBS2513986 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/mL Range 0.313-20ng/mL

PA2G4, ELISA Kit - MBS2510492 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 75pg/mL Range 125-8000pg/mL

PA2G4, ELISA Kit - MBS2513821 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/mL Range 0.313-20ng/mL

ProlifeRation Associated Protein 2G4 (PA2G4), ELISA Kit - MBS9315586 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Proliferation Associated Protein 2G4 (PA2G4), ELISA Kit - MBS2023139 from MyBioSource Category ELISA Kit Prices $410.00, $610.00, $830.00, $3,420.00, $6,200.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of PA2G4 is typically less than 0.128ng/mL. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined by adding two standard deviations to the mean optical density value of twenty zero standard replicates and calculating the corresponding concentration. Range 0.312-20ng/mL

ELISA Kit for Proliferation Associated Protein 2G4 (PA2G4) - SEL980Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.128ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

ELISA Kit for Proliferation Associated Protein 2G4 (PA2G4) - SEL980Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.128ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA's were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Mouse PA2G4 / EBP1 ELISA Kit (Competitive EIA) - LS-F18396 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.625 ng/ml Range 0.312-20 ng/ml

Human PA2G4 / EBP1 ELISA Kit (Custom ELISA) - LS-F18395 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.312-20 ng/ml

Human PA2G4(Proliferation Associated Protein 2G4) ELISA Kit - E-EL-H0868 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 0.19 ng/mLng/mL Range 0.31~20 ng/mL

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