| Gene Symbol |
PA2G4
|
| Entrez Gene |
5036
|
| Alt Symbol |
EBP1, HG4-1, p38-2G4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
proliferation-associated 2G4, 38kDa
|
| Other Description |
ErbB-3 binding protein 1|ErbB3-binding protein Ebp1|cell cycle protein p38-2G4 homolog|erbB3-binding protein 1|proliferation-associated 2G4, 38kD|proliferation-associated protein 2G4
|
| Swissprots |
Q9UM59 O43846 Q9UQ80
|
| Accessions |
AAD05561 EAW96884 EAW96885 Q9UQ80 AK291796 BAF84485 BC001951 AAH01951 BC007561 AAH07561 BC019222 AAH19222 BC032111 AAH32111 BC069786 AAH69786 BC072007 AAH72007 BU683753 DQ893446 ABM84372 DQ896751 ABM87750 U50137 AAA91484 U59435 AAB91536 U87954 AAD00646 NM_006191 NP_006182
|
| Function |
May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity). {ECO:0000250|UniProtKB:P50580, ECO:0000250|UniProtKB:Q6AYD3, ECO:0000269|PubMed:11268000, ECO:0000269|PubMed:12682367, ECO:0000269|PubMed:15064750, ECO:000026
|
| Subcellular Location |
Isoform 1: Cytoplasm {ECO:0000269|PubMed:16832058, ECO:0000269|PubMed:19037095}. Nucleus, nucleolus {ECO:0000269|PubMed:16832058, ECO:0000269|PubMed:19037095}. Note=Tranlocates to the nucleus upon treatment with HRG. Phosphorylation at Ser-361 by PKC/PRKCD regulates its nucleolar localization. {ECO:0000269|PubMed:16832058}.
|
| Tissue Specificity |
Isoform 2 is undetectable whereas isoform 1 is strongly expressed in cancer cells (at protein level). Isoform 1 and isoform 2 are widely expressed, including heart, brain, lung, pancreas, skeletal muscle, kidney, placenta and liver. {ECO:0000269|PubMed:10682683, ECO:0000269|PubMed:15064750, ECO:0000269|PubMed:19037095}.
|