PA2G4

Gene Symbol PA2G4
Entrez Gene 5036
Alt Symbol EBP1, HG4-1, p38-2G4
Species Human
Gene Type protein-coding
Description proliferation-associated 2G4, 38kDa
Other Description ErbB-3 binding protein 1|ErbB3-binding protein Ebp1|cell cycle protein p38-2G4 homolog|erbB3-binding protein 1|proliferation-associated 2G4, 38kD|proliferation-associated protein 2G4
Swissprots Q9UM59 O43846 Q9UQ80
Accessions AAD05561 EAW96884 EAW96885 Q9UQ80 AK291796 BAF84485 BC001951 AAH01951 BC007561 AAH07561 BC019222 AAH19222 BC032111 AAH32111 BC069786 AAH69786 BC072007 AAH72007 BU683753 DQ893446 ABM84372 DQ896751 ABM87750 U50137 AAA91484 U59435 AAB91536 U87954 AAD00646 NM_006191 NP_006182
Function May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity). {ECO:0000250|UniProtKB:P50580, ECO:0000250|UniProtKB:Q6AYD3, ECO:0000269|PubMed:11268000, ECO:0000269|PubMed:12682367, ECO:0000269|PubMed:15064750, ECO:000026
Subcellular Location Isoform 1: Cytoplasm {ECO:0000269|PubMed:16832058, ECO:0000269|PubMed:19037095}. Nucleus, nucleolus {ECO:0000269|PubMed:16832058, ECO:0000269|PubMed:19037095}. Note=Tranlocates to the nucleus upon treatment with HRG. Phosphorylation at Ser-361 by PKC/PRKCD regulates its nucleolar localization. {ECO:0000269|PubMed:16832058}.
Tissue Specificity Isoform 2 is undetectable whereas isoform 1 is strongly expressed in cancer cells (at protein level). Isoform 1 and isoform 2 are widely expressed, including heart, brain, lung, pancreas, skeletal muscle, kidney, placenta and liver. {ECO:0000269|PubMed:10682683, ECO:0000269|PubMed:15064750, ECO:0000269|PubMed:19037095}.

EBP1 CRISPR/Cas9 KO Plasmid (h) - sc-402177 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EBP1 HDR Plasmid (h) - sc-402177-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EBP1 Double Nickase Plasmid (h) - sc-402177-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EBP1 Double Nickase Plasmid (h2) - sc-402177-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EBP1 CRISPR Activation Plasmid (h) - sc-402177-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EBP1 CRISPR Activation Plasmid (h2) - sc-402177-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EBP1 Lentiviral Activation Particles (h) - sc-402177-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EBP1 Lentiviral Activation Particles (h2) - sc-402177-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EBP1 siRNA (h) - sc-77220 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

EBP1 shRNA Plasmid (h) - sc-77220-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

EBP1 shRNA (h) Lentiviral Particles - sc-77220-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU108931 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN16243 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16243 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08069 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr08069

PA2G4 siRNA (Human) - CRH3348 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PA2G4/EBP1 RNAi - H00005036-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

shRNA set against Human PA2G4(NM_006191.2) - SHR076990 from Creative biogene

Category siRNA
Species Reactivities Human

PA2G4 shRNA Plasmid (Human) - CHH3348 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PA2G4 miRNA 3'UTR clone - MiUTR1H-07453 from Creative biogene

Species Reactivities Human
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