PA2G4

Gene Symbol PA2G4
Entrez Gene 5036
Alt Symbol EBP1, HG4-1, p38-2G4
Species Human
Gene Type protein-coding
Description proliferation-associated 2G4, 38kDa
Other Description ErbB-3 binding protein 1|ErbB3-binding protein Ebp1|cell cycle protein p38-2G4 homolog|erbB3-binding protein 1|proliferation-associated 2G4, 38kD|proliferation-associated protein 2G4
Swissprots Q9UM59 O43846 Q9UQ80
Accessions AAD05561 EAW96884 EAW96885 Q9UQ80 AK291796 BAF84485 BC001951 AAH01951 BC007561 AAH07561 BC019222 AAH19222 BC032111 AAH32111 BC069786 AAH69786 BC072007 AAH72007 BU683753 DQ893446 ABM84372 DQ896751 ABM87750 U50137 AAA91484 U59435 AAB91536 U87954 AAD00646 NM_006191 NP_006182
Function May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity). {ECO:0000250|UniProtKB:P50580, ECO:0000250|UniProtKB:Q6AYD3, ECO:0000269|PubMed:11268000, ECO:0000269|PubMed:12682367, ECO:0000269|PubMed:15064750, ECO:000026
Subcellular Location Isoform 1: Cytoplasm {ECO:0000269|PubMed:16832058, ECO:0000269|PubMed:19037095}. Nucleus, nucleolus {ECO:0000269|PubMed:16832058, ECO:0000269|PubMed:19037095}. Note=Tranlocates to the nucleus upon treatment with HRG. Phosphorylation at Ser-361 by PKC/PRKCD regulates its nucleolar localization. {ECO:0000269|PubMed:16832058}.
Tissue Specificity Isoform 2 is undetectable whereas isoform 1 is strongly expressed in cancer cells (at protein level). Isoform 1 and isoform 2 are widely expressed, including heart, brain, lung, pancreas, skeletal muscle, kidney, placenta and liver. {ECO:0000269|PubMed:10682683, ECO:0000269|PubMed:15064750, ECO:0000269|PubMed:19037095}.

EBP1 (C-11) - sc-393114 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
EBP1 (C-11): sc-393114. Western blot analysis of EBP1 expression in K-562 (A), Jurkat (B), T-47D (C), HeLa (D) and Hep G2 (E) whole cell lysates.

EBP1 (H-300) - sc-292466 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
EBP1 (H-300): sc-292466. Western blot analysis of EBP1 expression in K-562 (A), T-47D (B) and Jurkat (C) whole cell lysates.

EBP1 (N-18) - sc-68477 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
EBP1 (N-18): sc-68477. Western blot analysis of EBP1 expression in Jurkat (A), PANC-1 (B), A2058 (C), HEK293 (D) and A375 (E) whole cell lysates.

EBP1 (P-19) - sc-68478 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

EBP1 (T-21) - sc-133531 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
EBP1 (T-21): sc-133531. Western blot analysis of EBP1 expression in HeLa whole cell lysate.

Anti-EBP1 antibody - ab186846 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human stomach cancer tissue labelling EBP1 with ab186846 at 1/200. Magnification: 400x.

Anti-EBP1 antibody - ab135525 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-EBP1 antibody (ab135525) at 1/50 dilutionLane 1 : MCF7 cell line lysateLane 2 : A2058 cell line lysateLysates/proteins at 35 µg per lane.

Anti-EBP1 antibody - ab37649 from Abcam

Prices $406.00
Sizes 50 µg
Host Chicken
Clonality Polyclonal
Anti-EBP1 antibody (ab37649) at 1/2000 dilution + E coli derived fusion protein SecondaryGoat anti IgY HRP at 1/1000 dilutiondeveloped using the ECL technique

Anti-EBP1 antibody - ab82858 from Abcam

Prices $304.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-EBP1 antibody (ab82858) at 1/50 dilution + Jurkat cell line lysates at 35 µg

Anti-EBP1 antibody - ab89439 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-EBP1 antibody (ab89439) at 1 µg/ml + Human pancreas lysate at 50 µgdeveloped using the ECL technique

Anti-EBP1 antibody [1D3] - ab119037 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1D3
All lanes : Anti-EBP1 antibody [1D3] (ab119037) at 1/2000 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY controlLane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY EBP1 cDNALysates/proteins at 5 µg per lane.

Anti-EBP1 antibody [EPR14568(B)] - ab180603 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR14568(B)
Flow cytometric analysis of 2% paraformaldehyde-fixed Jurkat cells labeling EBP1 with ab180603 at 1/20 dilution (red) compared to a Rabbit monoclonal IgG Isotype control (green), followed by Goat anti rabbit IgG (FITC) at 1/150 dilution.

Anti-EBP1 antibody [EPR14569(B)] - ab180602 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR14569(B)
Western blot analysis of Jurkat lysate immunoprecipitated with ab180602 at 1/30 dilution (Lane 1). Lane 2: Negative control. Anti-Rabbit IgG (HRP) secondary antibody, specific to the non-reduced form of IgG, used at 1/1500 dilution.

Anti-EBP1 antibody [PA2GF5F8] - ab51357 from Abcam

Host Mouse
Clonality Monoclonal
Clone PA2GF5F8
Anti-EBP1 antibody [PA2GF5F8] (ab51357) + immunizing peptide

Anti-PA2G4 / EBP1 Antibody (clone PA2GF5F8) - LS-C342370 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone PA2GF5F8
Western blot analysis of immunized recombinant protein, using anti-PA2G4 monoclonal antibody.

Anti-PA2G4 / EBP1 Antibody (clone 2A5) - LS-C197833 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2A5
Immunofluorescence of monoclonal antibody to PA2G4 on HeLa cell . [antibody concentration 10 ug/ml]

Anti-PA2G4 / EBP1 Antibody (aa228-255) - LS-C97341 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
EBP1 Antibody IHC of formalin-fixed and paraffin-embedded mouse brain tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-PA2G4 / EBP1 Antibody - LS-C334022 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded human stomach cancer using PA2G4 antibody at dilution of 1:200 (400x lens).

Anti-PA2G4 / EBP1 Antibody (aa301-350) IHC-plus™ - LS-B6878 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-EBP1 antibody IHC of human lung, respiratory epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6878 concentration 5 ug/ml.

Anti-PA2G4 / EBP1 Antibody - LS-C75084 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-PA2G4 / EBP1 Antibody (C-Terminus) - LS-C145237 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PA2G4 / EBP1 antibody LS-C145237 Western blot of Mouse Brain lysate. Antibody concentration 1 ug/ml.

Anti-PA2G4 / EBP1 Antibody (clone PA2GF5F8) - LS-C184318 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone PA2GF5F8

Anti-PA2G4 / EBP1 Antibody (aa178-227) - LS-C81085 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane A: Marker. Lane B: HepG2 cell lysate. Antibody concentration: 1.25 ug/ml. Gel concentration: 12%.

Anti-PA2G4 / EBP1 Antibody (aa300-345) - LS-C289784 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PA2G4 / EBP1 Antibody (aa345-394) - LS-C289785 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Search more