PA2G4

Gene Symbol	PA2G4
Entrez Gene	5036
Alt Symbol	EBP1, HG4-1, p38-2G4
Species	Human
Gene Type	protein-coding
Description	proliferation-associated 2G4, 38kDa
Other Description	ErbB-3 binding protein 1|ErbB3-binding protein Ebp1|cell cycle protein p38-2G4 homolog|erbB3-binding protein 1|proliferation-associated 2G4, 38kD|proliferation-associated protein 2G4
Swissprots	Q9UM59 O43846 Q9UQ80
Accessions	AAD05561 EAW96884 EAW96885 Q9UQ80 AK291796 BAF84485 BC001951 AAH01951 BC007561 AAH07561 BC019222 AAH19222 BC032111 AAH32111 BC069786 AAH69786 BC072007 AAH72007 BU683753 DQ893446 ABM84372 DQ896751 ABM87750 U50137 AAA91484 U59435 AAB91536 U87954 AAD00646 NM_006191 NP_006182
Function	May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity). {ECO:0000250|UniProtKB:P50580, ECO:0000250|UniProtKB:Q6AYD3, ECO:0000269|PubMed:11268000, ECO:0000269|PubMed:12682367, ECO:0000269|PubMed:15064750, ECO:000026
Subcellular Location	Isoform 1: Cytoplasm {ECO:0000269|PubMed:16832058, ECO:0000269|PubMed:19037095}. Nucleus, nucleolus {ECO:0000269|PubMed:16832058, ECO:0000269|PubMed:19037095}. Note=Tranlocates to the nucleus upon treatment with HRG. Phosphorylation at Ser-361 by PKC/PRKCD regulates its nucleolar localization. {ECO:0000269|PubMed:16832058}.
Tissue Specificity	Isoform 2 is undetectable whereas isoform 1 is strongly expressed in cancer cells (at protein level). Isoform 1 and isoform 2 are widely expressed, including heart, brain, lung, pancreas, skeletal muscle, kidney, placenta and liver. {ECO:0000269|PubMed:10682683, ECO:0000269|PubMed:15064750, ECO:0000269|PubMed:19037095}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human EBP1 full length protein - ab95350 from Abcam Category Protein Source E. coli Species Human

Human EBP1 peptide - ab35422 from Abcam Category Peptide

Human EBP1 peptide - ab35423 from Abcam Category Peptide

PA2G4 / EBP1 Antibody Blocking Peptide - LS-E7148 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PA2G4 / EBP1 Antibody Blocking Peptide - LS-E21162 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PA2G4 / EBP1 Antibody Blocking Peptide - LS-E17256 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PA2G4 / EBP1 Antibody Blocking Peptide - LS-E17255 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PA2G4/EBP1 Recombinant Protein - H00005036-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

PA2G4/EBP1 Partial Recombinant Protein - H00005036-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human PA2G4/EBP1 Protein - NBP1-44474 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

PA2G4-Antibody-Center-P205-Blocking-Peptide - BP2848c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

EBP1-Antibody-Center-Blocking-Peptide - BP2848a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PA2G4 Protein (OPPA01893) - OPPA01893 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human EBP1 protein (His Tag) - orb138721 from Biorbyt Category Protein Prices $357.00, $527.00 Sizes 50 μg, 100 μg Source E. coli Species Human

Human Proliferation-associated protein 2G4 protein - orb81253 from Biorbyt Category Protein Prices $230.00, $442.00 Sizes 5 μg, 25 μg Source E.coli Species Human

PA2G4 Blocking Peptide - 33R-5182 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PA2G4 Blocking Peptide - 33R-6656 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Pa2g4 Blocking Peptide - 33R-7021 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PA2G4 protein (His tag) - 80R-1311 from Fitzgerald Category Protein Prices $220.00 Sizes 100 µg Source E.coli

PA2G4 / EBP1 (1-394, His-tag) - AR09457PU-L from Acris Antibodies Category Protein Prices $695.00 Sizes 500 µg Source E. coli Species Human

PA2G4 / EBP1 (1-394, His-tag) - AR09457PU-N from Acris Antibodies Category Protein Prices $305.00 Sizes 100 µg Source E. coli Species Human

PA2G4 / EBP1 - H00005036-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

PA2G4 / EBP1 - H00005036-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

PA2G4 / EBP1 - H00005036-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PA2G4 / EBP1 - H00005036-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

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