SMARCC2

Gene Symbol	SMARCC2
Entrez Gene	6601
Alt Symbol	BAF170, CRACC2, Rsc8
Species	Human
Gene Type	protein-coding
Description	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
Other Description	BRG1-associated factor 170|SWI/SNF complex 170 kDa subunit|SWI/SNF complex subunit SMARCC2|SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2|SWI3-like protein|chromatin remodeling complex BAF170 subunit|mammalian chromatin remodeling complex BRG1-associated factor 170
Swissprots	Q96GY4 Q96E12 Q8TAQ2 Q59GV3 F8VTJ5 Q92923
Accessions	EAW96906 EAW96907 EAW96908 Q8TAQ2 AB209006 BAD92243 AB209293 BAD92530 AK025128 AK293896 BAG57283 AK315153 AL833124 CAH56218 BC009067 AAH09067 BC013045 AAH13045 BC026222 AAH26222 BC040645 BE326466 BQ272432 BT009924 AAP88926 BX476347 CB850719 CX165574 EU176256 ABW03707 U66616 AAC50694 XM_005269101 XP_005269158 XM_005269102 XP_005269159 XM_005269103 XP_005269160 XM_005269104 XP_005269161 XM_011538693 XP_011536995 XM_011538694 XP_011536996 NM_001130420 NP_001123892 NM_003075 NP_003066 NM_139067 NP_620706
Function	Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Can stimulate the ATPase activity of the catalytic subunit of these complexes. May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACT
Subcellular Location	Nucleus.
Tissue Specificity	Ubiquitously expressed.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SMARCC2 overexpression lysate - LY408410 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

SMARCC2 293 Cell Lysate - 404629 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

SMARCC2/BAF170 Overexpression Lysate (Native) - NBL1-16232 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

BAF170 (h): 293 Lysate - sc-111021 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

BAF170 (h): 293T Lysate - sc-175518 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

BAF170 (h2): 293T Lysate - sc-113750 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

SMARCC2 Over-expression Lysate Product - GWB-799687 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

SMARCC2/BAF170 Overexpression Lysate (Native) - NBP2-10867 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

SMARCC2/BAF170 Overexpression Lysate (Native) - NBP2-11321 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

Panoply™ Human SMARCC2 Knockdown Stable Cell Line - CSC-DC014730 from Creative biogene Category Cell Line Species Human

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