SMARCC2

Gene Symbol	SMARCC2
Entrez Gene	6601
Alt Symbol	BAF170, CRACC2, Rsc8
Species	Human
Gene Type	protein-coding
Description	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
Other Description	BRG1-associated factor 170|SWI/SNF complex 170 kDa subunit|SWI/SNF complex subunit SMARCC2|SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2|SWI3-like protein|chromatin remodeling complex BAF170 subunit|mammalian chromatin remodeling complex BRG1-associated factor 170
Swissprots	Q96GY4 Q96E12 Q8TAQ2 Q59GV3 F8VTJ5 Q92923
Accessions	EAW96906 EAW96907 EAW96908 Q8TAQ2 AB209006 BAD92243 AB209293 BAD92530 AK025128 AK293896 BAG57283 AK315153 AL833124 CAH56218 BC009067 AAH09067 BC013045 AAH13045 BC026222 AAH26222 BC040645 BE326466 BQ272432 BT009924 AAP88926 BX476347 CB850719 CX165574 EU176256 ABW03707 U66616 AAC50694 XM_005269101 XP_005269158 XM_005269102 XP_005269159 XM_005269103 XP_005269160 XM_005269104 XP_005269161 XM_011538693 XP_011536995 XM_011538694 XP_011536996 NM_001130420 NP_001123892 NM_003075 NP_003066 NM_139067 NP_620706
Function	Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Can stimulate the ATPase activity of the catalytic subunit of these complexes. May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACT
Subcellular Location	Nucleus.
Tissue Specificity	Ubiquitously expressed.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® SMARCC2 siRNA II - 7624 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

SignalSilence ® SMARCC2 siRNA I - 7431 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

BAF170 CRISPR/Cas9 KO Plasmid (h) - sc-402023 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

BAF170 HDR Plasmid (h) - sc-402023-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

BAF170 Double Nickase Plasmid (h) - sc-402023-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

BAF170 Double Nickase Plasmid (h2) - sc-402023-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

BAF170 CRISPR Activation Plasmid (h) - sc-402023-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

BAF170 CRISPR Activation Plasmid (h2) - sc-402023-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

BAF170 Lentiviral Activation Particles (h) - sc-402023-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

BAF170 Lentiviral Activation Particles (h2) - sc-402023-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

BAF170 siRNA (h) - sc-29782 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

BAF170 shRNA Plasmid (h) - sc-29782-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

BAF170 shRNA (h) Lentiviral Particles - sc-29782-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

SMARCC2/BAF170 RNAi - H00006601-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

SMARCC2/BAF170 RNAi - H00006601-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU090811 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN19768 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19768 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

SMARCC2 siRNA (Human) - CRH4484 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

SMARCC2 - MBS8222548 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human SMARCC2 (NM_003075.3) - SHH413172 from Creative biogene Category siRNA Species Reactivities Human

Human SMARCC2 siRNA - orb264986 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

SMARCC2 shRNA Plasmid (Human) - CHH4484 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

SMARCC2 miRNA 3'UTR clone - MiUTR3H-04357 from Creative biogene Species Reactivities Human

SMARCC2 miRNA 3'UTR clone - MiUTR3H-04358 from Creative biogene Species Reactivities Human

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