| Gene Symbol |
MYLK2
|
| Entrez Gene |
85366
|
| Alt Symbol |
KMLC, MLCK, MLCK2, skMLCK
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
myosin light chain kinase 2
|
| Other Description |
myosin light chain kinase 2, skeletal muscle|myosin light chain kinase 2, skeletal/cardiac muscle
|
| Swissprots |
Q96I84 Q569L1 Q9H1R3
|
| Accessions |
EAW76414 EAW76415 EAW76416 EAW76417 Q9H1R3 AF325549 AAK15494 AJ272502 CAC81354 BC007753 AAH07753 BC069627 AAH69627 BC092413 AAH92413 BC127622 AAI27623 BX647635 F22840 XR_244155 NM_033118 NP_149109
|
| Function |
Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N- terminus of a myosin light chain. {ECO:0000269|PubMed:11733062}.
|
| Subcellular Location |
Cytoplasm. Note=Colocalizes with phosphorylated myosin light chain (RLCP) at filaments of the myofibrils.
|
| Tissue Specificity |
Heart and skeletal muscles. Increased expression in the apical tissue compared to the interventricular septal tissue.
|
| Top Pathways |
Focal adhesion, Calcium signaling pathway, Vascular smooth muscle contraction, Gastric acid secretion, Oxytocin signaling pathway
|
![Western Blot: MYLK2 Overexpression Lysate (Adult Normal) [NBP2-05916] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for MYLK2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/16696_MYLK2%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBP2-05916-img0001.jpg)